| 二甲双胍治疗多囊卵巢综合征效果观察 |
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| 引用本文： | 张会娟,李道明,欧阳军.二甲双胍治疗多囊卵巢综合征效果观察[J].郑州大学学报(医学版),2006,41(6):1154-1156. |
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| 作者姓名： | 张会娟 李道明 欧阳军 |
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| 作者单位： | 郑州大学第一附属医院内分泌科,郑州,450052;郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室,郑州,450052;河南省医学科学研究所内分泌研究室,郑州,450052 |
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| 摘 要： | 目的:观察二甲双胍对多囊卵巢综合征(PCOS)的治疗效果.方法:选择PCOS患者24例,给予二甲双胍片1 500 mg/d,治疗6个月.检测患者治疗前、后和停药4个月的血清黄体生成素(LH)、睾酮(T)水平、口服葡萄糖耐量和胰岛素释放,观察月经变化和排卵情况.结果:二甲双胍治疗6个月后,17例(70.8%)患者恢复规律的排卵性月经.LH、T、空腹胰岛素、胰岛素曲线下面积较治疗前下降(P＜0.05),但在停药后4个月又恢复到治疗前水平(P＜0.05.停药4个月内,已恢复排卵性月经的患者又相继停经.结论:二甲双胍是一种有效的治疗PCOS的药物,但在停药后病情易于复发,提示在妊娠后应该继续应用二甲双胍治疗.
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| 关 键 词： | 多囊卵巢综合征 胰岛素抵抗 二甲双胍 |
| 收稿时间： | 2006-02-25 |
| 修稿时间： | 2006年5月25日 |
Effect of metformin on patients with polycystic ovary syndrome |
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| ZHANG Huijuan,LI Daoming,OUYANG Jun.Effect of metformin on patients with polycystic ovary syndrome[J].Journal of Zhengzhou University: Med Sci,2006,41(6):1154-1156. |
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| Authors: | ZHANG Huijuan LI Daoming OUYANG Jun |
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| Institution: | 1. Department of Endocrinology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052; 2. Department of Pathology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 ;3. Laboratory of Endocrinology, Institute of Medical Sciences of Henan, Zhengzhou 450052 |
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| Abstract: | Aim: To investigate the effect of metformin on patients with polycystic ovary syndrome (PCOS). Methods: A total of 24 patients with PCOS received metformin at 1 500 mg per day for six months. Serum levels of luteinizing hormone (LH), testosterone(T), OGTT, and releasing insulin were measured before and after treatment and 4 months after withdrawal of metformin. The menses and ovulation were observed.Results: A total of 17 cases (70.8%) patients resumed regular menstrual cycles with ovulation, and the serum levels of LH, T, fasting insulin and the areas below the insulin releasing curve decreased significantly (P<0.05). At 4 months after withdrawal of metformin treatment a reversal was observed.Conclusion: Metformin is an effective drug for PCOS, but the symptoms will recur before long after the withdrawal of metformin, which suggests that patients should keep using it during pregnancy. |
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| Keywords: | polycystic ovary syndrome insulin resistance metformin |
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