Role of Endothelium-Dependent Mechanism in Formation of Systemic Hemodynamic Responses to Hypervolemia |
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| Authors: | L. I. Osadchii T. V. Balueva I. V. Sergeev |
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| Affiliation: | Laboratory of Blood Circulation Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. |
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| Abstract: | Blockade of NO synthesis in anesthetized rats significantly potentiated pressor responses to Polyglucin (by 70%) and considerably increased total peripheral resistance. It was concluded that vasodilatation induced by increased systemic blood flow (cardiac output) modulates pressor responses under conditions of increased blood volume. |
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| Keywords: | blood volume cardiac output arterial blood pressure blockade of nitric oxide synthesis |
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