| 冠心病,糖尿病和系统性红斑狼疮患者的可溶性血管内皮细？… |
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| 引用本文： | 吴竞生,周志中.冠心病,糖尿病和系统性红斑狼疮患者的可溶性血管内皮细？…[J].中华血液学杂志,2000,21(9):472-474. |
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| 作者姓名： | 吴竞生 周志中 |
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| 作者单位： | 安徽省立医院 |
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| 基金项目： | 安徽省自然科学基金资助项目!(98452234) |
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| 摘 要： | 目的：检测冠心病（ＣＨＤ）、糖尿病（ＤＭ）、系统性红斑狼疮（ＳＬＥ）患血浆中的可溶性血管内皮细胞蛋白Ｃ受体（ｓＥＰＣＲ）水平，以探讨ｓＥＰＣＲ在不同疾病患血浆中表达水平及其临床意义。方法采用酶联免疫双抗体夹心法检测３４例ＣＨＤ、４２例ＤＭ、６３例ＳＬＥ患及２０名正常人（ＮＣ）血浆中的ｓＥＰＣＲ水平。结果ｓＰＥＣＲ在ＤＭ患血浆中的表达水平明显高于正常对照血浆（Ｐ〈０．０５）；ＳＬＥ合并血栓及
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| 关 键 词： | 冠心病 糖尿病 系统性红斑狼疮 sEPCR |
| 修稿时间： | 2000-03-20 |
Detection
of soluble endothelial protein C receptor(sEPCR) in patients with CHD, DM and SLE |
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| WU Jingsheng,ZHOU Zhizhong,YE Shandong.Detection
of soluble endothelial protein C receptor(sEPCR) in patients with CHD, DM and SLE[J].Chinese Journal of Hematology,2000,21(9):472-474. |
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| Authors: | WU Jingsheng ZHOU Zhizhong YE Shandong |
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| Institution: | Department of Hematology, Anhui Provincial Hospital, Hefei 230001, China. |
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| Abstract: | OBJECTIVE: To evaluate the clinical significance of plasma soluble endothelial protein C receptor (sEPCR) level in patients with coronary heart disease (CHD), diabetes mellitus (DM) and systemic lupus erythematosus (SLE). METHODS: ELISA of antibody-sandwiched principle was used to detect sEPCR in 34 patients with CHD, 42 with DM-II, 63 with SLE and 20 normal controls (NC). RESULTS: The plasma level of sEPCR in patients with DM was higher than that in NC group (P < 0.05). The sEPCR level in SLE patients with thrombosis and non-thrombosis are higher than that in NC group (P < 0.005 and P < 0.001, respectively). There is no significant difference between the two groups of SLE (P > 0.05), and between the CHD and NC groups. CONCLUSION: sEPCR level increased in DM and SLE, it seems related to the process of inflammatory reaction and damage of endothelial cell. |
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| Keywords: | Endothelial cells Receptor protein C Diabetes Coronary arteriosclerosis |
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