| 磷酸肌酸钠对小鼠阿霉素心肌损伤的保护机制初探 |
| |
| 引用本文： | 赵文英,陈冬云,邢文,吴明,杨志敏,吉兆宁.磷酸肌酸钠对小鼠阿霉素心肌损伤的保护机制初探[J].中国临床药理学与治疗学,2011,16(3):259-262. |
| |
| 作者姓名： | 赵文英 陈冬云 邢文 吴明 杨志敏 吉兆宁 |
| |
| 作者单位： | 1. 皖南医学院附属弋矾山医院肿瘤内科,芜湖,241000,安徽
2. 皖南医学院附属弋矾山医院老年医学科,芜湖,241000,安徽 |
| |
| 基金项目： | 安徽省高等学校省级自然科学研究项目 |
| |
| 摘 要： | 目的:探讨磷酸肌酸钠对小鼠阿霉素心肌损伤的保护作用。方法:雌性BALB/C小鼠60只,建立阿霉素心肌病模型,随机分为磷酸肌酸钠组、阿霉素组、正常对照组。观察小鼠的一般情况,血清中心肌酶TnI、N端前脑钠肽(NT-proB-NP)及心肌组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、ATP酶及乳酸脱氢酶(LDH)的变化,心肌组织HE染色病理变化。结果:与阿霉素组比较,磷酸肌酸钠组LDH、MDA明显降低(P<0.05),SOD和ATP酶活力明显升高(P<0.05);血清NT-proBNP及TnI水平降低(P>0.05)。阿霉素组心肌组织出现明显的水肿、变性。结论:磷酸肌酸钠通过减少氧自由基对阿霉素所致的心肌损伤具有保护作用。
|
| 关 键 词： | 磷酸肌酸钠 阿霉素 心肌酶 氧自由基 |
Primary exploration on the protective effect of phosphocreatine sodium on adriamycin-induced cardiotoxicity in mice |
| |
| ZHAO Wen-ying,CHEN Dong-yun,XING Wen,WU Ming,YANG Zhi-min,JI Zhao-ning.Primary exploration on the protective effect of phosphocreatine sodium on adriamycin-induced cardiotoxicity in mice[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(3):259-262. |
| |
| Authors: | ZHAO Wen-ying CHEN Dong-yun XING Wen WU Ming YANG Zhi-min JI Zhao-ning |
| |
| Institution: | ZHAO Wen-ying1,CHEN Dong-yun1,XING Wen2,WU Ming2,YANG Zhi-min1,JI Zhao-ning11 Department of Medical Oncology,Yijishan Hospital of Wannan Medical College,2 Department of Elderly Medicine,Wuhu 241000,Anhui,China |
| |
| Abstract: | AIM: To observe the protective effect of phosphocreatine sodium on adriamycin-induced cardiotoxicity in mice.METHODS: 60 female BALB/C mice weighting about 20 g were randomly divided into control group(Con),adriamycin group(ADR) and phosphocreatine sodium treatment group(CP).The general condition,the serum myocardial enzymes of NT-proBNP and TnI,the changes of MDA,SOD,LDH and ATPase in cardiac tissues were detected.The changes of cardiac tissues were observed by HE staining.RESULTS:Compared with group ADR,t... |
| |
| Keywords: | Phosphocreatine sodium Adriamycin Myocardial enzyme Oxygen free radicals |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
