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| 奥拉西坦的临床前药理学研究 | |
| 引用本文： | 金磊,李博,叶雷,蔡云红,荣祖元. 奥拉西坦的临床前药理学研究[J]. 中国临床药理学与治疗学, 2011, 16(3): 354-360 |
| 作者姓名： | 金磊 李博 叶雷 蔡云红 荣祖元 |
| 作者单位： | 1. 四川抗菌素工业研究所药理部,成都,610052,四川 2. 第三军医大学西南医院神经外科,重庆,400038 3. 重庆东泽医药科技发展有限公司,重庆,400030 |
| 摘 要： | 促智药奥拉西坦的问世已有二十余年,国内外对其药理学特征进行了广泛而深入的研究。作为一个在一般药理学上无活性、无毒的认知增强剂,它具备良好的药代动力学特性,其药理作用包括对学习记忆的改善作用以及一定的神经保护作用,其作用机制可能涉及:对中枢胆碱能系统的作用以及其它与认知相关的递质系统(如谷氨酸系统、单胺递质系统)与胆碱能系统的相互作用;对长时程增强的诱导和维持作用;对蛋白激酶C的激活作用;对脑代谢的改善作用;以及外周类固醇激素的影响等。 |
| 关 键 词： | 奥拉西坦 促智药 认知增强剂 学习记忆 神经保护 |
Preclinical pharmacology research of oxiracetam |
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| JIN Lei,LI Bo,YE Lei,CAI Yun-Hong,RONG Zu-Yuan. Preclinical pharmacology research of oxiracetam[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(3): 354-360 | |
| Authors: | JIN Lei LI Bo YE Lei CAI Yun-Hong RONG Zu-Yuan |
| Affiliation: | JIN Lei1,LI Bo2,YE Lei3,CAI Yun-Hong3,RONG Zu-Yuan11 Department of Pharmacology,Sichuan Industrial Institute of Antibiotic,Chengdu 610052,Sichuan,China,2 Neurosurgery Department of Southwest Hospital,Third Military Medical University,Chongqing 400038,3 Dong Ze Pharmaceutical Science and Technology Co.Ltd,Chongqing 400030 |
| Abstract: | It has been more than 20 years since the birth of nootropic drug oxiracetam,extensive and deep research has been focused on its pharmacological features in china and abroad.As a general pharmacologically inactive and non-toxic cognition enhancer,it possesses good pharmacokinetics characteristics.The pharmacological effects of oxiracetam include the improvement of learning and memory and neuroprotective function.The mechanism of its action may involve: the effect on central acetylcholine system and the inter... |
| Keywords: | Oxiracetam Nootropic Cognition enhancer Learning and Memory Neuroprotective |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |