| 五味化痔胶囊快速薄层鉴别与定量测定研究 |
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| 引用本文： | 王智森,韩桂茹,高飞,安丽娜,纪玉哲. 五味化痔胶囊快速薄层鉴别与定量测定研究[J]. 中国药品标准, 2011, 12(3): 187-190 |
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| 作者姓名： | 王智森 韩桂茹 高飞 安丽娜 纪玉哲 |
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| 作者单位： | 1. 石家庄藏诺生物科技有限公司,石家庄,050051
2. 河北省药品检验所,石家庄,050011 |
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| 摘 要： | 目的:建立简便、快捷的五味化痔胶囊质量控制方法。方法:用TLC法鉴别大黄、地龙与人工牛黄,用HPLC法测定了胶囊中总的与游离的大黄酚、大黄素。结果:薄层鉴别斑点清晰,阴性无干扰。方法学研究表明,大黄酚进样量在0.046 8～0.819μg,大黄素的进样量在0.019 92～0.996μg,分别与峰面积呈良好的线性关系。大黄酚的平均回收率为99.77%(n=9),RSD为1.92%;大黄素的平均回收率为99.57%(n=9),RSD为1.53%。结论:方法简便、快捷、实用,能保证五味化痔胶囊的有效性与安全性。
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| 关 键 词： | 五味化痔胶囊 薄层色谱法 定量测定 大黄酚 大黄素 |
Studies on the rapid TLC identification and Determination for Wuwei Huanzhi Capsules |
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| Wang Zhi-sen,Han Gui-ru,Gao Fei,An Li-na and Ji Yu-zhe. Studies on the rapid TLC identification and Determination for Wuwei Huanzhi Capsules[J]. , 2011, 12(3): 187-190 |
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| Authors: | Wang Zhi-sen Han Gui-ru Gao Fei An Li-na Ji Yu-zhe |
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| Affiliation: | Wang Zhi-sen1,Han Gui-ru2,Gao Fei 1,An Li-na 1 Ji Yu-zhe(1.Shijiazhuang Zangnuo Biological Scientific Technology Company 2.Hebei Provincial Institute for Drug Control,Shijiazhuang 050011) |
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| Abstract: | Objective:To establish a simple and rapid method for the quality control of Wuwei Huazhi Capsules.Method:Radix et Rhizoma Rhei,Pheretima and Calculus Bovis Artifactus were identified by TLC at 2 thin-layer chromatographic plates.The contents of total and uncombined chrysophanol and emodin in the Wuwei Huazhi Capsules were determinated by HPLC.Results:The spots of TLC identification are clear.The negative sample has not interference.The methodological study showed that a good linear correlation existed in th... |
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| Keywords: | Wuwei Huazhi Capsules TLC Content determination chrysophanol emodin |
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