苯那普利联合霉酚酸酯治疗早期糖尿病肾病的疗效观察

目的:探讨苯那普利联合霉酚酸酯(MMF)治疗早期糖尿病肾病(DN)的临床疗效。方法:30例早期Ⅱ型糖尿病肾病(DN)患者,随机分为治疗组和对照组,治疗组使用苯那普利、霉酚酸酯(MMF)联用,对照组单用苯那普利,疗程12周。观察两组患者治疗前后的平均动脉压(MAP)、尿白蛋白排泄率(UAER)、内生肌酐清除率(Ccr)、血清肌酐(SCr)、空腹血糖(FBG)、糖化血红蛋白(HbA1C)、血脂等变化。结果:治疗组与观察组对早期DN均有明显降低血压、UAER、SCr的作用,各组在治疗前后差异具有明显统计学意义(P<0.01或P<0.05),但治疗组效果更好,尤其降低UAER作用有明显差异(P<0.01),各组间FBG、CH、TG治疗前及治疗后比较无统计学意义。结论:苯那普利联合MMF治疗早期DN有确切疗效。

Study on Therapeutic Effect of Benazpril Combined with MMF on Early Diabetic nephropathy

Objective To observe the therapeutic effect of Benazpril combined with MMF on diabetic nephropathy.Methods The treatment group was treated with Benazpril combined with MMF,while the observation group with benazpril alone;Both groups were observed for determination of MAP,UAER,CCr,SCr,FBG and HbA1C,etc.before initiation of therapy and after treatment for 12 weeks.Results Significant decrease was detected in blood pressure,UAER and BUN(P<0.01 or P<0.05);the treatment group's decrease especially in UAER was more significant(P<0.01);little significance was Detected interms of FBG,CH and TG(P>0.05).Conclusion Benazpril combined with MMF has definite therapeutic effect on early DN.