超早期大剂量尿激酶治疗白发性脑室出血 |
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引用本文: | 董海海,王永和,曹培成,程迎新.超早期大剂量尿激酶治疗白发性脑室出血[J].青岛医药卫生,2013,45(2):96-98. |
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作者姓名: | 董海海 王永和 曹培成 程迎新 |
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作者单位: | 董海海 (潍坊医学院外科学教研室,山东潍坊,261053); 王永和 (潍坊市人民医院脑科医院神经外一科); 曹培成 (潍坊市人民医院脑科医院神经外一科); 程迎新 (潍坊市人民医院脑科医院神经外一科); |
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摘 要: | 目的探讨超早期大剂量尿激酶治疗自发性脑室出血的临床疗效。方法将72例自发性脑室出血患者随机分为A组(超早期组)、B组(早期组)、C组(延期组),分别于出血后6~8h、8~72h和72ht之后应用尿激酶治疗。3组均行侧脑室外引流加大剂量尿激酶灌注治疗,术后观察治疗并随访1~6个月。结果1个月后,A组和B组的再出血、感染、继发脑积水率及存活率均优于C组(1P〈0.05);6个月后,A组日常生活能力(ADI。)显著优于B组和C组(P〈0.05)。结论超早期大剂量尿激酶灌注治疗自发性脑室出血,可降低术后并发症的发生率,提高患者的存活率和生存质量。
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关 键 词: | 自发性 脑室出血 超早期 大剂量 尿激酶 |
Treatment of spontaneous intraventricular hemorrhage with high-dose urokinase in the ultra-early stage |
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Institution: | DONG Hai-hai , WANG gong-he, CAO Pei-cheng , CHENG ging-xin. Department of Surgery ,Weifang Medical College, Weifang, Shandong 261053, China |
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Abstract: | Objective To investigate the clinical effect of high-dose urokinase in treating spontaneous intraventricular hemorrhage in the ultra-early stage. Methods After admission,72 cases of spontaneous intraventricular hemorrhage were randomly divided into group A, B and C. The patients in group A were operated by perfusing with high-dose urokinase within 6-8 hours af- ter bleeding, group B more than 8 hours and less than or equal to 72 hours and group C more than 72 hours. Then they were treated with observation and followed up for 1-6 months. Results Af- ter 1 month, the rates of rehaemorrhagia, infection, secondary hydrocephalus and the survival rate of group A and B were better than group C (P〈0.05). After 6 months,The ADL of group A was significantly better than group B and C (P〈0.05). Conclusion Ultra-early perfusion therapy with high-dose urokinase can reduce the incidence of postoperative complications of spon- taneous intraventricular hemorrhage and improve the patients' survival rate and quality of life. |
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Keywords: | Spontaneous Intraventricular hemorrhage Ultra-early High-dose Uroki- nase |
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