| 酚妥拉明对野百合碱引起的大鼠肺动脉高压的影响 |
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| 引用本文： | 范纯富,王怀良.酚妥拉明对野百合碱引起的大鼠肺动脉高压的影响[J].中国药理学通报,1992,8(5):391-393. |
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| 作者姓名： | 范纯富 王怀良 |
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| 作者单位： | 沈阳医学院药理学教研室 沈阳110031
(范纯富)，中国医科大学药理教研室 沈阳110001
(王怀良)，中国医科大学药理教研室 沈阳110001(赵乃才) |
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| 基金项目： | 卫生部七·五攻关资金资助 |
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| 摘 要： | 本文研究结果表明:野百合碱是一个有效的引起Wistar大鼠肺动脉高压模型的药物;酚妥拉明(0.2mg·kg~(-1)0.4mg·kg~(-1))im.每天2次.连续用药21d后.可降低野百合碱引起的肺动脉高压.但对股动脉血压无明显影响。酚妥拉明(0·52mg·kg~(_1))iv一次即可明显降低野百合碱引起的大鼠肺动脉高压和股动脉压。
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| 关 键 词： | 酚妥拉明 野百合碱 肺动脉高压 股动脉压 |
Effect of phentolamine on pulmonary hypertension induced by monocrotaline in rats |
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| FAN Chun-Fu,WANG Huai -Liang. ZHAO Nai-Cai.Effect of phentolamine on pulmonary hypertension induced by monocrotaline in rats[J].Chinese Pharmacological Bulletin,1992,8(5):391-393. |
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| Authors: | FAN Chun-Fu WANG Huai -Liang ZHAO Nai-Cai |
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| Abstract: | The effect of phentolamine on pulmonary hypertension induced by monocrotaline was observed in rats. The results suggested that monocrotaline was an effective agent that induced pulmonary hypertension in Wistar's rats and phentolamine (0.2mg · kg-1. 0.4mg · kg-1) using intramuscular injection twice every day after 21d . might decrease pulmonary
hypertevsion induced by monocrotaline. but had no effect on femoral arterial pres-sure. Phentolamine ( 0.2mg·kg-1) using intravenous injection could decrease pulmonary hypertension induced by monocro - taline and femoral arterial pressure. |
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| Keywords: | phentolamine monocro taline pulmonary hypertension femora-tarterial pressure |
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