| 铝暴露对海马NMDA受体的影响 |
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| 引用本文： | 岳志军,邢伟.铝暴露对海马NMDA受体的影响[J].解剖科学进展,2008,14(4). |
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| 作者姓名： | 岳志军 邢伟 |
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| 作者单位： | 中国医科大学基础医学院生物,化学与分子生物学教研室,辽宁,沈阳,110001 |
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| 摘 要： | 铝是一种慢性神经毒性物质,能影响神经系统的多种功能,特别是对学习和记忆功能有抑制作用。铝可通过改变神经细胞的膜功能和NMDA受体等途径影响细胞内外的钙稳态,造成细胞结构和功能障碍,导致学习记忆能力出现不同程度的下降。NMDA受体是中枢谷氨酸盐兴奋性受体的一种,参与突触可塑性及皮质和海马神经元长时程增强(LTP)效应。NMDA受体通道在学习记忆中开启和学习记忆、神经元可塑性及大脑发育等方面均起重要作用。
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| 关 键 词： | 海马NMDA受体 学习记忆能力 NMDA受体通道 铝 神经毒性物质 神经元可塑性 长时程增强 海马神经元 |
Effect of Aluminum Exposure on NMDA Receptors of Rat Hippocampus |
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| YUE Zhi-jun,XING Wei.Effect of Aluminum Exposure on NMDA Receptors of Rat Hippocampus[J].Progress of Anatomical Sciences,2008,14(4). |
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| Authors: | YUE Zhi-jun XING Wei |
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| Institution: | YUE Zhi-jun,XING Wei (Department of Biochemisty , Molecular Biology,College of Basic Medicine,China Medical University,Shenyang 110001 China) |
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| Abstract: | Aluminum is one of the chronicity neurovirulence, effects many neurologic functions, especially for learning and memory inhibitory action. Aluminum can change nerve cell pellicula functions and N-methyl-D-Aspartate receptor (NMDA) to influence the calcium balance of cells to cause the cellular structure and functional disturbance, resulting in the different degrees of decline in the learning and memory capacity.NMDA receptor is one of the excitatory receptors of central glutamate, involves in the synaptic p... |
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