舒血宁注射液加重头孢曲松钠致凝血障碍1例

1例31a男性患者,因治疗病毒性脑炎继发的细菌感染,静脉输入注射用头孢曲松钠2g＋0.9%氯化钠注射液100mL。7d后,患者双前臂静脉输液处瘀斑扩大,查凝血象：PT15.2s,INR1.31,APTT16.9s,Fbg1.00g·L-1,TT22.8s。怀疑药源性凝血障碍,停用头孢曲松钠,肌内注射维生素K1每天10mg。为改善微循环,第2天静脉滴注舒血宁注射液20mL＋0.9%氯化钠注射液500mL,7d后患者凝血象PT34.1s,INR2.87,APTT超出检测范围,Fbg0.70g·L-1,TT22.9s,遂停用舒血宁注射液,4d后凝血象基本恢复正常。

One case report of blood coagulation disorders due to ceftriaxone sodium aggravated by Shuxuening injection

A 31-year-old man received 2g of ceftriaxone sodium dissolved in 100 mL of 0.9% sodium chloride injection by intravenous infusion for curing the secondary bacterial infection.Ecchymosis of the site for intravenous infusion of both forearm extended 7 days later.Results of coagulogram were PT 15.2 s,INR 1.31,APTT 16.9 s,Fbg 1.00 g·L-1,TT 22.8 s.Stopped using ceftriaxone sodium,10 mg per day of vitamin K1 was given by intramuscular injection.The next day,he received an intravenous infusion of Shuxuening injection,which was dissolved in 500 mL of 0.9% sodium chloride injection.Seven days later,results of coagulogram were PT 34.1 s,INR 2.87,Fbg 0.70 g·L-1,TT 22.9 s,and APTT was out of detection range.Shuxuening injection was discontinued.His coagulogram returned to normal four days later.