| 载药微球与空白微球联合表阿霉素治疗肝细胞癌的临床对比研究 |
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| 引用本文： | 李映辰,金书强,王凯冰,朱章祥,苏国庆,姜波,白彬. 载药微球与空白微球联合表阿霉素治疗肝细胞癌的临床对比研究[J]. 医学影像学杂志, 2019, 0(4): 608-612 |
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| 作者姓名： | 李映辰 金书强 王凯冰 朱章祥 苏国庆 姜波 白彬 |
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| 作者单位： | 哈尔滨医科大学附属第二医院介入科;哈尔滨医科大学附属第一医院康复科 |
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| 摘 要： | 目的探讨并对比在经导管肝动脉化疗栓塞术(TACE)中使用载药微球或空白微球联合表阿霉素治疗肝细胞癌的临床效果和安全性。方法对50例经临床确诊分期为BCLC-A/B期的肝细胞癌患者,随机分成两组A、B,每组25人。分别行TACE,其中A组使用Hepasphere载药微球进行栓塞,B组使用相同粒径的Embosphere空白微球进行栓塞。两组均采用改良实体瘤疗效评价标准(mRECIST)评价疗效,并比较患者治疗前后肝功能及甲胎蛋白变化,观察并记录术后不良反应、并发症的发生情况。结果两组共50例患者均顺利接受TACE,技术成功率为100%。两组分别随访6个月,根据mRECIST标准,A组:3个月疾病缓解率CR+PR为92%, 6个月CR+PR为88%。B组:3个月疾病缓解率CR+PR为84%,6个月CR+PR为80%。术后3个月复查患者肝功能情况,两组患者肝功能与术前差异均无统计学意义,所有患者均未出现肝脓肿、肿瘤破裂、消化道出血、胆囊炎、胆汁漏并发感染等严重并发症。结论对BCLC-A/B期肝细胞癌患者,应用载药微球相比空白微球进行TACE治疗近期临床效果和安全性都更有优势,远期疗效尚待进一步观察。
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| 关 键 词： | 载药微球 空白微球 肝细胞癌 介入性,放射学 |
Clinical comparison of Drug-loaded beads and blank microspheres combined with epirubicin in treatment of hepatocellular carcinoma |
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| LI Yingchen,JIN Shuqiang,WANG Kaibing,ZHU Zhangxiang,SU Guoqing,JIANG Bo,BAI Bin. Clinical comparison of Drug-loaded beads and blank microspheres combined with epirubicin in treatment of hepatocellular carcinoma[J]. Journal of Medical Imaging, 2019, 0(4): 608-612 |
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| Authors: | LI Yingchen JIN Shuqiang WANG Kaibing ZHU Zhangxiang SU Guoqing JIANG Bo BAI Bin |
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| Affiliation: | (Department of Interventional Radiology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,P.R.China;Department of Kangfu,The First Affiliated Hospital of Harbin Medical University,Harbin 150000,P.R.China) |
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| Abstract: | LI Yingchen;JIN Shuqiang;WANG Kaibing;ZHU Zhangxiang;SU Guoqing;JIANG Bo;BAI Bin(Department of Interventional Radiology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,P.R.China;Department of Kangfu,The First Affiliated Hospital of Harbin Medical University,Harbin 150000,P.R.China) |
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| Keywords: | Drug-loaded microspheres Blank microspheres Hepatocellular carcinoma Transcatheter arterial chemoembolization Interventional Radiology |
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