| 不同危险因素的急性脑梗死患者血清超敏C反应蛋白、神经元特异性烯醇化酶含量的变化及其临床意义 |
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| 引用本文： | 贾姝婧,史春夏,李立华.不同危险因素的急性脑梗死患者血清超敏C反应蛋白、神经元特异性烯醇化酶含量的变化及其临床意义[J].实用临床医药杂志,2019,23(10):61-64. |
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| 作者姓名： | 贾姝婧 史春夏 李立华 |
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| 作者单位： | 北京市通州区永乐店社区卫生服务中心全科,北京,101105;首都医科大学附属北京潞河医院肾内科,北京,100149 |
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| 摘 要： | 目的 探讨不同危险因素的急性脑梗死(ACI)患者血清超敏C反应蛋白(hs-CRP)、神经元特异性烯醇化酶(NSE)含量的变化及临床意义。 方法 选取20例健康对照者与68例急性脑梗死患者,根据危险因素将脑梗死患者分为单纯脑梗死组、脑梗死合并高血压病组、脑梗死合并糖尿病组。采用酶联免疫吸附实验测定血清中hs-CRP、NSE的浓度,比较不同危险因素脑梗死患者hs-CRP及NSE含量变化。采用美国国立卫生院卒中量表(NIHSS)评估神经缺损程度。 结果 ACI患者入院血清hs-CRP、NSE浓度显著高于健康对照组(P<0.01)。ACI患者中,脑梗死合并高血压组、脑梗死合并糖尿病组患者血清hs-CRP、NSE浓度显著高于单纯脑梗死患者(P<0.05)。ACI患者血清hs-CRP、NSE浓度与NIHSS评分呈线性正相关。Pearson相关分析显示,ACI患者血清hs-CRP水平与NSE水平呈显著线性正相关(P<0.05)。 结论 急性脑梗死患者合并高血压病、糖尿病会加重血管炎性反应及神经功能损害。
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| 关 键 词： | 脑梗死 超敏C反应蛋白 神经元特异性烯醇化酶 美国国立卫生院神经功能缺损评分 高血压 糖尿病 |
Clinical significance and changes of serum high-sensitivity C reactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors |
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| JIA Shujing,SHI Chunxia,LI Lihua.Clinical significance and changes of serum high-sensitivity C reactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors[J].Journal of Clinical Medicine in Practice,2019,23(10):61-64. |
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| Authors: | JIA Shujing SHI Chunxia LI Lihua |
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| Institution: | (General Medical Department,Yongle Town Community Health Center of Tongzhou District in Beijing,Beijing,101105;Department of Nephrology,Beijing Luhe Hospital Affiliated to Capital Medical University,Beijing,101149) |
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| Abstract: | JIA Shujing;SHI Chunxia;LI Lihua(General Medical Department,Yongle Town Community Health Center of Tongzhou District in Beijing,Beijing,101105;Department of Nephrology,Beijing Luhe Hospital Affiliated to Capital Medical University,Beijing,101149) |
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| Keywords: | cerebral infarction high-sensitivity C reactive protein neuron-specific enolase National Institutes of Health Neurological Deficiency Score hypertension diabetes mellitus |
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