| 胰石蛋白在呼吸机相关性肺炎患者支气管肺泡灌洗液及呼出气冷凝液中的表达及检测价值 |
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| 引用本文： | 黄云峰,周帆,徐晓林. 胰石蛋白在呼吸机相关性肺炎患者支气管肺泡灌洗液及呼出气冷凝液中的表达及检测价值[J]. 实用临床医药杂志, 2019, 23(11): 99-102 |
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| 作者姓名： | 黄云峰 周帆 徐晓林 |
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| 作者单位： | 湖北省黄冈市中心医院急诊医学科,湖北黄冈,438000;湖北省黄冈市中心医院全科医学科,湖北黄冈,438000;湖北省黄冈市中心医院保健科,湖北黄冈,438000 |
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| 摘 要： | 目的观察胰石蛋白(PSP)在呼吸机相关性肺炎(VAP)患者支气管肺泡灌洗液(BALF)及呼出气冷凝液(EBC)中的表达并探讨其检测价值。方法采用酶联免疫吸附法(ELISA)分别检测40例VAP患者VAP疑诊当日及VAP诊断当日BALF、EBC中的PSP表达水平,同期选择40例行机械通气治疗而未出现VAP的患者作为对照组。比较2组患者不同时点BALF、EBC中PSP表达水平,采用受试者工作特征(ROC)曲线法分析BALF、EBC中PSP水平检测对VAP的诊断价值。结果VAP组患者疑诊当日、诊断当日的BALF、EBC中PSP表达水平均显著高于对照组(P<0.05),2组患者VAP诊断当日的BALF、EBC中PSP表达水平均显著高于VAP疑诊当日(P<0.05),2组患者同时点的BALF中PSP表达水平均显著高于EBC(P<0.05);VAP诊断当日BALF中PSP的曲线下面积为0.91,高于VAP诊断当日EBC中PSP和VAP疑诊当日BALF、EBC中PSP的曲线下面积,虽然灵敏度(87.50%)低于EBC中PSP(92.50%),但特异度(80.00%)高于EBC中PSP(67.50%)。结论检测BALF、EBC中PSP水平对于VAP早期诊断具有较高的临床价值,尤其是BALF中PSP水平检测的价值更高。
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| 关 键 词： | 胰石蛋白 呼吸机相关性肺炎 支气管肺泡灌洗液 呼出气冷凝液 |
Expression of pancreatic stone protein in bronchoalveolar lavage fluid and exhaled breath condensate of patients with ventilator-associated pneumonia and its detection value |
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| HUANG Yunfeng,ZHOU Fan,XU Xiaolin. Expression of pancreatic stone protein in bronchoalveolar lavage fluid and exhaled breath condensate of patients with ventilator-associated pneumonia and its detection value[J]. Journal of Clinical Medicine in Practice, 2019, 23(11): 99-102 |
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| Authors: | HUANG Yunfeng ZHOU Fan XU Xiaolin |
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| Affiliation: | (Department of Emergency Medicine,Huanggang Central Hospital in Hubei Province,Huanggang,Hubei,438000;Department of General Medicine,Huanggang Central Hospital in Hubei Province,Huanggang,Hubei,438000;Department of HealthCare,Huanggang Central Hospital in Hubei Province,Huanggang,Hubei,438000) |
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| Abstract: | HUANG Yunfeng;ZHOU Fan;XU Xiaolin(Department of Emergency Medicine,Huanggang Central Hospital in Hubei Province,Huanggang,Hubei,438000;Department of General Medicine,Huanggang Central Hospital in Hubei Province,Huanggang,Hubei,438000;Department of HealthCare,Huanggang Central Hospital in Hubei Province,Huanggang,Hubei,438000) |
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| Keywords: | pancreatic stone protein ventilator-associated pneumonia bronchoalveolar lavage fluid exhaledbreath condensate |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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