| 温阳利水化瘀方联合西医常规疗法治疗慢性充血性心力衰竭阳虚血瘀证临床研究 |
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| 引用本文： | 陈学彬,吉锋,李联社,赵明君. 温阳利水化瘀方联合西医常规疗法治疗慢性充血性心力衰竭阳虚血瘀证临床研究[J]. 中国中医药信息杂志, 2019, 0(11): 31-35 |
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| 作者姓名： | 陈学彬 吉锋 李联社 赵明君 |
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| 作者单位： | 陕西中医药大学附属医院;陕西省中西医结合心血管病防治重点实验室 |
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| 基金项目： | 陕西省重点研发计划(2017SF-277) |
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| 摘 要： | 目的观察温阳利水化瘀方联合西医常规疗法治疗慢性充血性心力衰竭(CHF)阳虚血瘀证患者的临床疗效,及对血管张力和心肌重构的影响。方法采用随机数字表法将89例CHF患者分为联合组45例和西药组44例。西药组予“金三角”标准方案;联合组在西药组基础上加用温阳利水化瘀方,每日1剂,每日2次,口服。2组均连续治疗1个月。观察2组治疗前后6min步行试验、中医症状积分、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)及血清脑利钠肽(BNP)、内皮素(ET)水平,监测2组不良反应。结果联合组总有效率为71.1%(32/45),西药组为50.0%(22/44),联合组明显优于西药组(P<0.05)。与本组治疗前比较,2组治疗后6min步行试验距离增加,LVEF提高,LVEDD、LVESD缩短,中医症状积分下降,血清BNP、ET水平下降(P<0.05,P<0.01);2组治疗后比较,联合组6min步行距离、各项心功能指标、中医症状积分及血清BNP、ET水平明显优于西药组(P<0.05,P<0.01)。联合组未见明显不良反应。结论温阳利水化瘀方联合西医常规疗法治疗CHF阳虚血瘀证患者可提高临床疗效,改善血管张力和心肌重构。
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| 关 键 词： | 温阳利水化瘀方 慢性充血性心力衰竭 脑利钠肽 内皮素 |
Clinical Study on Wenyang Lishui Huayu Prescription Combined with Western Routine Therapy for Treatment of Chronic Congestive Heart Failure with Yang Deficiency and Blood Stasis Syndrome |
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| CHEN Xuebin,JI Feng,LI Lianshe,ZHAO Mingjun. Clinical Study on Wenyang Lishui Huayu Prescription Combined with Western Routine Therapy for Treatment of Chronic Congestive Heart Failure with Yang Deficiency and Blood Stasis Syndrome[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2019, 0(11): 31-35 |
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| Authors: | CHEN Xuebin JI Feng LI Lianshe ZHAO Mingjun |
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| Affiliation: | (Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China;Key Laboratory of Cardiovascular Disease Prevention and Control of Integrated Traditional Chinese and Western Medicine,Xianyang 712000,China) |
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| Abstract: | CHEN Xuebin;JI Feng;LI Lianshe;ZHAO Mingjun(Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China;Key Laboratory of Cardiovascular Disease Prevention and Control of Integrated Traditional Chinese and Western Medicine,Xianyang 712000,China) |
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| Keywords: | Wenyang Lishui Huayu Prescription chronic congestive heart failure brain natriuretic peptide endothelin |
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