宫颈癌骨转移临床相关因素分析及探讨

目的探讨宫颈癌骨转移相关因素。方法回顾分析2008年6月-2011年8月收治的352例宫颈癌患者的临床资料,其中鳞癌326例,腺癌26例;临床分期Ⅰ期60例、Ⅱ期184例、Ⅲ期90例、Ⅳ期18例。比较不同期别、不同病理类型、不同组织分级患者的骨转移情况。结果 352例宫颈癌中有18例发现骨转移,转移率为5.1%;转移时间为3～48个月,2例于骨转移后1年内死亡。鳞癌326例,骨转移率为5.2%;腺癌26例,骨转移率为3.8%。Ⅰ、Ⅱ、Ⅲ和Ⅳ期患者的骨转移率分别为0.0%、3.8%、5.6%和33.3%,晚期与早期相比有统计学意义(P<0.05);高、中和低分化患者骨转移率分别为3.1%、3.1%和6.3%,高分化与中分化相比,差异无统计学意义(P>0.05),低分化与高中分化相比差异有统计学意义(P<0.05)。结论宫颈癌骨转移与宫颈癌临床分期、病理类型、细胞分级密切相关。在宫颈癌的治疗过程中,做到早发现、早治疗,可提高患者的治疗效果,延长生存时间。

Analysis of the Clinical Factors Related to Bone Metastasis of Cervical Cancer

Objective To study the factors related to bone metastasis of cervical cancer.Methods We retrospectively analyzed the clinical data of 352 patients with cervical cancer treated from June 2008 to August June 2011.Among them,there were 326 cases of squamous cell carcinoma and 26 cases of adenocarcinoma.The number of clinical stage Ⅰ,Ⅱ,Ⅲ and Ⅳ cancer were respectively 60,184,90 and 18.Bone metastasis of different stages,pathological types and grades were compared and analyzed.Results Eighteen cases of bone metastasis occurred out of 352 cervical cancer patients with a total incidence of 5.1%.Metastasis occurred 3 to 48 months after cancer diagnosis,and 2 patients died within one year after bone metastasis was diagnosed.The metastasis rate was 5.2% in the 326 patients with squamous cell carcinoma and 3.8% in the 26 patients with adenocarcinoma.The incidences of bone metastasis of stage Ⅰ,Ⅱ,Ⅲ and Ⅳ were 0.0%,3.8%,5.6% and 33.3% respectively.There was a significant difference between early stages and late stages(P < 0.05).Bone metastasis of grade 1,2 and 3 were 3.3%,3.1% and 6.3% respectively.There was no significant difference between grade 1 and 2,but there was a significant difference between grade 3 and grade 1 or 2(P < 0.05).Conclusions Bone metastasis of cervical cancer is greatly associated with clinical stage,pathological type and cell grade.Early diagnosis and management may improve the treatment efficacy and the survival of patients.