胰胆管合流异常与胆囊癌关系的Meta分析

目的综合评价胰胆管合流异常(PBM)与胆囊癌发生的关系,为胆囊癌的预防提供更多、更准确的信息。方法计算机检索中国生物医学文献数据库(CBM)、中国期刊网(CNKI)、PubMed、EMBASE、万方等数据库,检索时间从1977年4月-2011年5月,并结合文献追溯的方法,收集国内外公开发表的关于PBM与胆囊癌关系的病例对照研究或队列研究,采用RevMan 5.0.25软件进行Meta分析。结果总计纳入文献8篇,其中3篇仅对比分析了PBM在胆囊癌患者与正常对照组中发生率的差异,2篇仅对比分析了胆囊癌在PBM患者与正常对照组中发生率的差异,而另外3篇文献则对这两种发生率的差异都进行了对比。Meta分析结果显示:胆囊癌患者中PBM的发生率明显高于正常对照组,差异有统计学意义[OR=7.41,95%CI(5.03,10.87),P<0.000 01];且PBM患者中胆囊癌的发生率明显高于正常对照组,差异有统计学意义[OR=17.67,95%CI(10.43,29.94),P<0.000 01]。结论 PBM是胆囊癌发生的高危因素,与胆囊癌的发生密切相关。

Association between Pancreaticobiliary Maljunction and Gallbladder Carcinoma:A Meta-Analysis

Objective To comprehensively evaluate the association between pancreaticobiliary maljunction(PBM) and gallbladder carcinoma(GBC),in order to provide more accurate information for the prevention of gallbladder carcinoma.Methods A full literature search from April 1977 to May 2011 was conducted in CBM,CNKI,PubMed,EMBASE,Wanfang databases to identify case-control studies or cohort studies evaluating the relationship between PBM and the risk of gallbladder carcinoma.Meta-analysis was performed using RevMan 5.0.25 software.Results In the total of eight studies,only three of them investigated the difference in the incidence of PBM between GBC patients and controls,and only two of them investigated the difference in the incidence of GBC between PBM patients and controls.But the other three studies investigated these two kinds of differences.Meta-analysis revealed that the incidence of PBM was higher in the GBC patients than that of the controls [OR=7.41,95%CI(5.03,10.87),P<0.000 01],and the incidence of GBC was higher in the PBM patients than that of the controls [OR =17.67,95%CI(10.43,29.94),P<0.000 01].Conclusion PBM is a high-risk factor for GBC,significantly associated with the development of gallbladder carcinoma.