术前新辅助化疗在局部晚期宫颈癌患者中的应用

目的：探讨术前新辅助化疗（NACT）在局部晚期宫颈癌患者治疗中的疗效及毒副反应。方法76例局部晚期宫颈癌患者根据是否接受NACT分为两组，其中观察组39例给予NACT后再接受根治性切除术治疗，而对照组37例患者直接接受单纯根治性切除术治疗，评价NACT治疗后的有效率以及两组术后情况。结果观察组NACT的有效率为76.9%，主要毒副反应为轻度恶心呕吐及骨髓抑制，未影响治疗的顺利进行。观察组淋巴结转移率及术后复发率均低于对照组（P〈0.05）。结论 NACT有利于局部晚期宫颈癌的完全切除，能够降低患者淋巴结转移及术后复发的可能。

Preoperative neoadjuvant chemotherapy in the patients with locally advanced cervical cancer

Objective To investigate the efficacy and toxicities of preoperative neoadjuvant chemotherapy （NACT） in the treatment of patients with locally advanced cervical cancer. Methods The 76 patients with locally advanced cervical cancer patients were divided into two groups, 39 patients of the observation group received the NACT and radical operation, while 37 patients of the control group directly received radical operation, the response rate of NACT and the postoperative conditions of the two groups were evaluated comparatively. Results The response rate of NACT was 76.9%in the observation group, the main toxicities were mild nausea and vomiting, and bone marrow suppression, they did not affect the smooth progress of treatment. The lymph node metastasis rate and the recurrence rate of the observation group were lower than those of the control group （P＆lt;0.05）. Conclusion NACT is in favor of total resection of locally advanced cervical cancer, and it can reduce the possibility of lymph node metastasis and recurrence of the patients with locally advanced cervical cancer.