Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced behavioral sensitization in mice |
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Authors: | Sahraei Hedayat Faghih-Monzavi Zohreh Fatemi Sayedeh Maedeh Pashaei-Rad Shahrokh Salimi Seyed Hossein Kamalinejad Mohammad |
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Institution: | Department of Physiology and Biophysics, and Behavioral Sciences Research Center (BSRC), School of Medicine, Baqiyatallah, University of Medical Sciences, Tehran, Iran. h.sahraei@bmsu.ac.ir |
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Abstract: | In the present study, the effects of a water-alcohol extract of Papaver rhoeas on the acquisition and expression of morphine-induced behavioral sensitization in mice were investigated. The subcutaneous (s.c.) administration of morphine (50 mg/kg) induced locomotor activity in animals, whereas the drug did not show an effect at a dose of 5 mg/kg. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. The locomotor behavioral response was enhanced in mice pretreated with morphine (5 mg/kg, daily x 3 days) alone, indicating that sensitization had developed. Extract (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of the three daily doses of morphine decreased the development of sensitization. Moreover, intraperitoneal administration of the plant extract (25, 50 and 100 mg/kg) 30 min before the test reduced the expression of morphine-induced behavioral sensitization.The results indicate that administration of the extract of Papaver rhoeas reduced the acquisition and expression of morphine-induced behavioral sensitization in mice. |
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Keywords: | Papaver rhoeas morphine mice behavioral sensitization |
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