Relative bioavailability of terbutaline to the lung following inhalation, using urinary excretion |
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| Authors: | Abdelrahim Mohamed E Assi Khaled H Chrystyn Henry |
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| Affiliation: | 1Faculty of Pharmacy, University of Beni Suef, Beni Suef, Egypt;2Institute of Pharmaceutical Innovation, University of Bradford, Bradford;3Faculty of Pharmacy, The Division of Pharmacy and Pharmaceutical Sciences, School of Applied Sciences, University of Huddersfield, Huddersfield, UK |
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| Abstract: | AIMSThe aim of the study was to determine the relative lung and systemic bioavailability of terbutaline.METHODSOn separate days healthy volunteers received 500 µg terbutaline study doses either inhaled from a metered dose inhaler or swallowed as a solution with and without oral charcoal. Urine samples were provided at timed intervals post dosing.RESULTSMean (SD) urinary terbutaline 0.5 h post inhalation, in 12 volunteers, with (IC) and without (I) oral charcoal and oral (O) dosing was 7.4 (2.2), 6.5 (2.1) and 0.2 (0.2) µg. I and IC were similar and both significantly greater than O (P < 0.001). Urinary 24 h terbutaline post I was similar to IC + O. The method was linear and reproducible, similar to that of the urinary salbutamol method.CONCLUSIONSThe urinary salbutamol pharmacokinetic method post inhalation applies to terbutaline. Terbutaline study doses can replace routine salbutamol during these studies when patients are studied. |
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| Keywords: | inhalation lung terbutaline urinary excretion |
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