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Blood infectivity in transmissible spongiform encephalopathies
Authors:Dickmeiss Ebbe  Gerstoft Jan
Affiliation:Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark. dickmeis@rh.dk
Abstract:Blood infectivity in transmissible spongiform encephalopathies (TSE) is reviewed with special emphasis on transmission by blood transfusion in human beings. It is concluded that transmission by transfusion seems biologically plausible as regards variant Creutzfeld-Jakob Disease (vCJD), albeit present knowledge suggests that it is extremely uncommon. Precautionary measures against the putative risk of vCJD transmission by blood transfusion are discussed.
Keywords:Prion disease    disease transmission    blood transfusion    vCJD
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