| 一氧化氮吸入对支气管哮喘疗效的初步观察 |
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| 引用本文： | 张洪玉,杨媛华.一氧化氮吸入对支气管哮喘疗效的初步观察[J].中华内科杂志,1995,34(12):805-807. |
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| 作者姓名： | 张洪玉 杨媛华 |
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| 作者单位： | 首都医科大学附属北京朝阳医院北京呼吸疾病医疗研究中心，首都儿科研究所 |
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| 摘 要： | 为了进一步了解一氧化氮（ＮＯ）吸入对支气管哮喘患者的治疗作用，兹选择中度支气管哮喘急性发作期的患者１０例，使用４０ｐｐｍ浓度的ＮＯ吸入２０分钟，在停止吸入后即刻进行临床和肺功能评价。结果发现，所有病人临床症状和肺部哮喘音均有不同程度好转。１秒钟用力呼气容积（ＦＥＶ＿１）、最大呼气流速（ＰＥＦ）改善均有显著性（Ｐ＜０．０５）。为了观察ＮＯ持续作用时间，１０例中各有５例分别在停止吸入ＮＯ２０分钟和２４小时后，重复测定上述肺功能参数，ＦＥＶ＿１及ＰＥＦ值均有增加。但因例数过少，尚难得出结论。本观察结果提示：低浓度ＮＯ吸入似可作为治疗支气管哮喘的一种方法。
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| 关 键 词： | 一氧化氮 哮喘 肺换气 |
A PRELIMINARY OBSERVATION ON THE EFFECTS OF INHALED NITRIC OXIDE ON BRONCHIAL ASTHMA |
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| Zhang Hongyu, yang yuanhua, Weng Xinzhi,et al..A PRELIMINARY OBSERVATION ON THE EFFECTS OF INHALED NITRIC OXIDE ON BRONCHIAL ASTHMA[J].Chinese Journal of Internal Medicine,1995,34(12):805-807. |
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| Authors: | Zhang Hongyu yang yuanhua Weng Xinzhi |
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| Institution: | Zhang Hongyu, yang yuanhua, Weng Xinzhi, et al.Beijing Respiratory Disease Research Center,Beijing Red Cross ChaoYang Hospital,Beijing 1 00020 |
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| Abstract: | itric oxide (NO)is a vasodilator as well as a bronchodilator.In order to estimate the therapeutic ef-fects of NO on bronchial asthma,10 patients in acute exacerbation stage were selected for this study,40ppm NO was inhaled for 20 minutes,The clinical stage and pulmonary function were evaluated instantly.The results showed that subjective symptoms were relieved and wheezing rales decreased to a different ex-tent.FEV_1 and PEF improved significently (P<0.05).It is suggested that low concentration NO inhala-tion can be used as a therapeutic measure for bronchial asthma. |
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| Keywords: | Nitric oxide Asthma Pulmorary gas exchange |
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