EFFECT OF DIETARY UREA ON BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS |
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Authors: | Hong Wang Katsumi Ikeda Masahiro Kihara Yasuo Nara Ryoichi Horie Yukio Yamori |
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Affiliation: | Japan Stroke Prevention Center and Department of Pathology, Shimane Medical University, Izumo, Japan,;*Shanghai Hypertension Institute, Shanghai, The People's Republic of China |
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Abstract: | The feeding of a normal diet containing 13.5% urea (in place of protein in a high protein diet) attenuated the development of severe hypertension and decreased the incidence of stroke in spontaneously hypertensive rats (SHR), when 1% NaCl solution was given to them. The urea not only increased urine volume, but also increased urinary sodium excretion in SHR given 1% NaCl for drinking. Although there was no obvious difference in erythrocyte size between the urea and the control groups, there was a significant inverse correlation between plasma urea level and erythrocyte size. These results suggest that a high protein diet reduced blood pressure partly through the diuretic effect of urea, the common metabolite of various proteins. |
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Keywords: | erythrocyte size, hypertension, SHR, stroke, urea, urinary sodium, urinary potassium. |
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