Clinical features of OKT4+/OKT8+ adult T-cell leukemia |
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| Authors: | K Tamura T Unoki K Sagawa Y Aratake T Kitamura N Tachibana S Ohtaki K Yamaguchi M Seita |
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| Institution: | 1. Department of Internal Medicine, Miyazaki Prefectural Hospital, Miyazaki Japan;2. Department of Immunology, Kurume University School of Medicine, Kurume Japan;3. Central Laboratory for Clinical Investigation, Miyazaki Medical College Hospital, Kiyotake Japan;4. Department of Virology, National Cancer Center, Tokyo Japan;5. The Second Department of Internal Medicine, Miyazaki Medical College, Kiyotake Japan;6. The Second Department of Internal Medicine, Kumamoto University, Kumamoto, Japan |
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| Abstract: | Adult T-cell leukemia (ATL) has a range of clinical characteristics. Phenotypically the leukemic cells usually express the helper/inducer associated antigen OKT4 with lack of OKT8. We have observed three patients with acute ATL cytologically indistinguishable from OKT4+/OKT8- ATL but whose neoplastic cells had the unusual phenotype, OKT3+, OKT4+, OKT6-, OKT8+ OKT9+/-, OKT11+, Tac+/-, TdT-. All patients had abnormal karyotypes and antibodies against anti-ATL associated antigens as well as proviral DNA of human T-cell leukemia virus in the leukemic cells. The clinical course was complicated by skin eruptions, hypercalcemia, pulmonary infection and disseminated intravascular coagulopathy. All died of complications shortly after diagnosis. The clinical features of these patients were similar to those of OKT4+/OKT8- ATL. However, their acute course suggests that co-expression surface antigens OKT4 and OKT8 may be a sign of aggressive nature of the disease with poor prognosis. |
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| Keywords: | Adult T-cell leukemia complex phenotype OKT4+/OKT8+ human T-cell leukemia virus adult T-cell leukemia human T-cell leukemia virus sheep erythrocytes antibody-complement-sensitized ox erythrocytes autologous erythrocytes surface immunoglobulin |
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