| 不同干细胞来源外泌体在牙周再生领域的研究进展 |
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| 引用本文： | 吴晓楠,马宁,侯建霞.不同干细胞来源外泌体在牙周再生领域的研究进展[J].国际口腔医学杂志,2020(2):146-151. |
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| 作者姓名： | 吴晓楠 马宁 侯建霞 |
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| 作者单位： | 青岛市口腔医院牙周科;青岛市市立医院东院区口腔科;北京大学口腔医院牙周科 |
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| 基金项目： | 青岛市卫生科技发展计划项目(2017-WJZD123)~~ |
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| 摘 要： | 牙周炎是由牙菌斑中的微生物所引起的慢性感染性疾病,可引起牙周支持组织的炎症和破坏,是成年人失牙的最主要原因。良好的菌斑控制可有效抑制炎症进展,然而目前在临床诊疗中,尚难以获得稳定的、令人满意的牙周组织再生。外泌体是真核细胞分泌的一种细胞外膜性微囊泡,可作为干细胞旁分泌活动的一种重要形式参与多种组织的再生。外泌体的应用为牙周组织再生提供了一种新策略,本文对不同干细胞来源外泌体在牙周再生领域的研究进展进行综述。
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| 关 键 词： | 外泌体 牙周再生 间充质干细胞 |
Research progress of exosomes derived from different stem cells in periodontal regeneration |
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| Wu Xiaonan,Ma Ning,Hou Jianxia.Research progress of exosomes derived from different stem cells in periodontal regeneration[J].Journal of International Stomatology,2020(2):146-151. |
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| Authors: | Wu Xiaonan Ma Ning Hou Jianxia |
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| Institution: | (Dept.of Periodontology,Qingdao Stomatological Hospital,Qingdao 266001,China;Dept.of Stomatology,Qingdao Municipal Hospital,Qingdao 266071,China;Dept.of Periodontology,Peking University School and Hospital of Stomatology,Beijing 100081,China) |
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| Abstract: | Periodontitis is a chronic infectious disease caused by dental plaque and the primary reason for tooth loss in adults because it damages periodontal supporting structures.Microbial plaque biofi lm control is an effective method to prevent further disease progression.However,a reliable treatment that can lead to stable and satisfactory periodontal regeneration in clinical practice has not been reported to date.Exosome is a specific class of lipid-membrane-bound extracellular vesicle.Exosomes are secreted from cells through paracrine mechanism and participate in tissue regeneration.Considering that the application of exosomes provides a new strategy for tissue regeneration,this review presents the current status of exosomes derived from different kinds of cells for potential therapeutic use in periodontal regeneration. |
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| Keywords: | exosome periodontal regeneration mesenchymal stem cell |
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