气泡式鼻塞持续气道正压通气预防及治疗新生儿呼吸窘迫综合征的临床分析

目的探讨气泡式鼻塞持续气道正压通气（BNCPAP）早期应用于预防和治疗新生儿呼吸窘迫综合征（NRDS）的l临床疗效。方法选取2010年1月～2011年4月于本院分娩后30rain内转入我科的58例早产儿为研究对象，分为预防组30例（治疗前未出现呼吸窘迫症状）和治疗组28例（治疗前出现呼吸窘迫症状），两组均于出生后30min内应用BNCPAP来预防和治疗NRDS，观察两组患儿的治疗效果，对其相关数据进行统计分析及比较。结果预防组预防成功率92_3％，预防后2h、12h、24hPa02／Fi02、PaC02值与预防前相比较有显著性差异（P〈0．05），预防后2h、12hpH值与预防前相比较无显著性差异（P〉0．05），预防后24hpH值与预防前相比较有显著性差异（P〈0．05）；治疗组治疗成功率89．3％，治疗后2h、12h、24hPa02／Fi02、PaC02值与治疗前相比较有显著性差异（P〈0．05），治疗后2hpH值与治疗前相比较无显著性差异（P〉0．05），治疗后12h、24hpH值与治疗前相比较有显著性差异（P〈0．05）。结论早期应用气泡式鼻塞持续气道正压通气（BNCPAP）预防和治疗早产儿呼吸窘迫综合征（NRDS）疗效显著，值得临床上合理推广应用。

Application of bubble nasal continuous positive airways pressure in prophylaxis and therapy of neonatal respiratory distress syndrome

Objective To evaluate the effect of bubble nasal continuous positive airways pressure （BNCPAP） in pro- phylaxis and therapy of neonatal respiratory distress syndrome （NRDS）. Methods From Jan 2010 to Apr 2011, 58 premature infants after the birth of 30 min and sent in department of paediatrics were selected as research object. The infants were divided into 2 groups： prophylactic group （n=30） which was given BNCPAP before development of dyspnea and non-prophylactic group （n=28） which was given BNCPAP after the development of dyspnea. After observing the therapeutic effect of the infants in the two groups, the related data was statistically analyzed and compared. Results The success ratio of prophylactic group was 92.3%. There had significant difference in PaO2/FiO2, PaCO2 before treatment and after 2h, 12h,24h treatment （P〈0.05）. There was not significant difference in pH before treatment and after 2h, 12h treatment （P〉0.05）. There had significant difference in pH before treatment and after 24h treatment （P〈0.05）. The success ratio of non-prophylactic group was 89.3%. There had sig- nificant difference in PaO2/FiO2,PaCO2 before treatment and after 2h, 12h,24h treatment （P〈0.05）. There was not significant difference in pH before treatment and after 2h treatment （P〉0.05）. There had significant difference in pH before treatment and after 12h,24h treatment （P〈0.05）. Conclusion The clinical curative effect of early application of bubble nasal continuous positive airways pressure （BNCPAP） in prophylaxis and therapy of neonatal respiratory distress syndrome （NRDS） is significant, and it is worthy of wide application in clinic.