肠易激综合征患者焦虑抑郁及睡眠障碍临床分析

目的通过比较肠易激综合征（IBS）患者与健康人在焦虑、抑郁、睡眠上的差异，探讨IBS患者的精神心理特点及睡眠特征。方法采用Zung氏焦虑自评表（SAS）、抑郁自评表（SDS）和匹兹堡睡眠指数表（PSQ1）对53例IBS患者及50例健康人进行评分。结果①IBS组的焦虑、抑郁评分及PSQI总分明显高于对照组（45．38±6．65v839．26±5．39：47．70±6．82vs40．96±5．28；6．54±2．34VS5．44-＋1．41；P〈0．05），且焦虑、抑郁患病率和PSQI阳性率明显高于对照组（P〈0．05）。女性IBS患者的焦虑、抑郁评分高于男性IBS患者（47．31±7．49VS43．57_＋4．39；49．99＋7．13VS44．24±4．64；P〈0．05）。②IBS组PSQI的睡眠质量、睡眠障碍、安眠药物和日间功能障碍的评分显著高于对照组（P〈0．05）。③焦虑或／和抑郁状态的IBS患者与无焦虑抑郁IBS患者PSQI总分相比差异性显著（P〈0．05）。结论IBS患者存在焦虑、抑郁及睡眠障碍较正常人多见．女性IBS患者发生焦虑、抑郁评分高于男性患者。焦虑、抑郁状态可加重IBS患者的睡眠障碍。

Clinical analysis of anxiety, depression and sleep disturbances in patients with IBS

Objective To discuss the psychological features and sleep quality of IBS patients by comparing the levels of anxiety and depression and sleep quality between IBS patients and healthy subjects. Methods 53 IBS patients and 50 healthy subjects were enrolled in the study. Anxiety and depression were assessed by self-rating anxiety scale（SAS） and self-rating de- pression scale （SDS）. Sleep quality was evaluated by Pittsburgh sleep quality index （PSQI）. Results ①The scores of anxiety, depression and PSQI were significantly higher in IBS patients than those in healthy subjects （45.38±6.65 vs 39.26±5.39, 47.70± 6.82 vs 40.96±5.28,6.51±2.34 vs 5.44±1.41 ,P〈0.05）. The female IBS patients had higher scores of anxiety and depression than male patients （47.31±7.49 vs 43.57±4.39,49.99±7.13 vs 44.24±4.64,P〈0.05）. The prevalence of anxiety and depression and PSQI positive rate of IBS patients were significantly higher than those of healthy subjects （P〈0.05）. ②Compared with healthy subjects; , the scores of sleep quality,sleep disturb-antes,sleeping medication,daytime dysfunction were significantly higher in 1BS patients. ③IBS patients with anxiety or/and depression had higher pSQI scores than patients without anxiety and depression （P〈0.05）. Conclusion IBS patients frequently suffer more anxiety,depression and sleep disturb-antes than healthy subjects. The female IBS patients have higher scores of anxiety and depression than male patients. The state of anxiety and depression can exacerb~te the sleep disturbances in IBS patients.