拉莫三嗪治疗脑卒中后继发癫痫的疗效及不良反应观察

目的探讨拉莫三嗪治疗脑卒中后继发癫痫的疗效及不良反应。方法选取2009年5月～2012年11月在我院接受治疗的脑卒中后继发癫痫患者85例，按随机数字表法分为观察组（42例）和对照组（43例），其中观察组采用拉莫三嗪进行治疗，对照组采用卡马西平进行治疗，观察两组患者的治疗效果和临床不良反应。结果观察组患者癫痫控制8例，显效22例，有效10例，无效2例；出现不良反应情况：月经紊乱l例，饮食量减少1例，头痛1例，转氨酶升高1例。对照组患者癫痫控制5例，显效18例，有效10例，无效10例；不良反应：月经紊乱2例，转氨酶升高3例，饮食量减少3例，头痛1例，口角流涎1例，皮疹2例。结论拉莫三嗪治疗脑卒中后继发癫痫具有很好的疗效，患者病情可以得到很大改善甚至完全控制：而且不良反应少，适合临床推广使用。

Efficacy and adverse reactions of Lamotrigine in treating epilepsy secondary to stroke

Objective To explore the efficacy and reverse reactions of Lamotrigine in treating epilepsy secondary to stroke. Methods A total of 85 patients with epilepsy secondary to stroke who received treatment in our hospital from May 2009 to Nov 2012 were selected as subjects. All the patients were divided into observation group and control group with the method of random number table. Patients in the observation group were treated with Lamotrigine, those in the control group were treated with Carbamazepine, and then the therapeutic effects and clinical adverse reactions of two groups were observed. Re- sults Epilepsy of 8 cases in the observation group were controlled, 22 cases showed significant effectiveness, 10 cases showed effectiveness and 2 cases showed ineffectiveness. As for the adverse reactions, 1 case of menstrual disorder, 1 case of loss of appetite, 1 case of headache and 1 case of transaminase elevation were observed. In the control group, epilepsy of 5 cases were controlled, 18 cases showed significant effectiveness, 10 cases showed effectiveness and 10 cases showed ineffectiveness. As for the adverse reactions, 2 cases of menstrual disorder, 3 cases of transaminase elevation, 3 cases of loss of appetite, 1 case of headache, 1 case of slobbering and 2 cases of rash were observed. Conclusion Lamotrigine has good effects on epilepsy secondary to stroke. Patient＇s condition can be greatly improved even completely controlled. Besides, it has fewer adverse reac- tions, thus it is worthy of wide clinical application.