地佐辛注射液不良反应发生风险因素分析

目的：评价地佐辛不良反应发生相关风险因素，为临床合理用药提供参考信息。方法：通过我院HIS收集2013年地佐辛注射液使用情况，通过国家药品不良反应监测系统收集其不良反应发生情况并对所有使用患者核实以排除不良反应漏报情况；对年龄、性别等因素采用单因素和多因素Logistic回归，逐步向前法筛选变量。结果：2013年我院地佐辛注射液使用患者3257例，发生不良反应者56例。单因素和多因素Logistic回归分析均显示具有统计学意义（P<0.05）的影响因素为：性别、肝病、科室。结论：地佐辛不良反应的发生可能与性别、肝病和科室有关。

Analyzing the Risk Factors of Adverse Reactions Caused by Dezocine Injections

Objective:To assessment the risk factors of dezocine in order to provide reference information for the clinical rational use.Methods: Collected the utilization of dezocine in 2013 through HIS; collected the occurrence of adverse reactions through the national information system of monitoring adverse reaction and verified. The data collected are treated with univariate and multivariate analysis of variance, forward stepwise selection of variables. Results: Dezocine used in 3257 patients in 2013,adverse reaction occurred in 56 cases.The result of univariate and multivariate analysis of variance is that sex, departments, liver disease are the main risk factors(P<0.05). Conclusion:Adverse effects of dezocine may be associated with sex, liver disease and the department.