| 正交设计优化吗啡明胶微球的制备工艺 |
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| 引用本文： | 龙健晶,孙永海,张宏.正交设计优化吗啡明胶微球的制备工艺[J].军医进修学院学报,2009,30(4):570-571. |
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| 作者姓名： | 龙健晶 孙永海 张宏 |
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| 作者单位： | 解放军总医院麻醉科,北京,100853 |
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| 摘 要： | 目的通过正交设计筛选出吗啡明胶微球的最佳制备工艺。方法以微球粒径分布、载药量、包封率等为指标，采用正交设计法优化微球的制备工艺。结果微球形态良好，粒径符合要求，平均载药量为20．94％，包封率为86．27％，重现性良好。结论采用正交实验完成了吗啡明胶微球的制备工艺优化。
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| 关 键 词： | 吗啡 明胶微球 正交试验 |
Preparation of morphine gelatin microspheres by orthogonal design |
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| LONG Jian-jing,SUN Yong-hai,ZHANG Hong.Preparation of morphine gelatin microspheres by orthogonal design[J].Academic Journal of Pla Postgraduate Medical School,2009,30(4):570-571. |
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| Authors: | LONG Jian-jing SUN Yong-hai ZHANG Hong |
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| Institution: | LONG Jian-jing,SUN Yong-hai,ZHANG Hong Department of Anesthesia,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To study the optimal preparation conditions of morphine gelatin microspheres by orthogonal design. MethodsMorphine gelatin microspheres were prepared with the double emulsion method. Optimal preparation conditions were selected with orthogonal design combined with multi-index test. Mean diameter and size distribution of microspheres,drug loading and encapsulation efficiency were used as evaluating indicators. ResultsThe morphine gelatin microspheres produced by the selected procedure were good in ... |
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| Keywords: | morphine gelatin microspheres orthogonal test |
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