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Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia |
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| Authors: | C. Iadecola Colleen Forster Shigeru Nogawa H. Brent Clark M. Elizabeth Ross |
| Affiliation: | (1) Departments of Neurology and Neuroscience, University of Minnesota Medical School, Box 295 UMHC, 516 Delaware Street S.E., Minneapolis, MN 55455, USA e-mail: iadec001@tc.umn.edu Tel.: +1-612-624-1902, Fax: +1-612-625-7950, US;(2) Departments of Neurology and Laboratory Medicine and Pathology (Neuropathology), University of Minnesota, Minneapolis, MN 55455, USA, US |
| Abstract: | The prostaglandin synthesizing enzyme cyclooxygenase-2 (COX-2) is up-regulated in the brain of rodents during cerebral ischemia and contributes to ischemic brain injury. This study sought to determine whether COX-2 is also up-regulated in the human brain in the acute stages of cerebral ischemic infarction. Paraffin-embedded sections from patients who died 1–2 days following infarction in the middle cerebral artery territory were processed for COX-2 immunohistochemistry. COX-2 immunoreactivity was observed in infiltrating neutrophils, in vascular cells and in neurons located at the border of the infarct. The data suggest that COX-2 up-regulation is also relevant to cerebral ischemia in humans and raise the possibility that COX-2 reaction products participate in the mechanisms of ischemic injury also in the human brain. Received: 12 January 1999 / Revised, accepted: 8 March 1999 |
| Keywords: | Prostaglandin H2 synthase Stroke Inflammation Immunohistochemistry Prostaglandins |
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