皮肌炎和多发性肌炎并发头颈部恶性肿瘤

目的：观察皮肌炎(DM)和多发性肌炎(PM)与头颈部恶性肿瘤的关系。方法：收集1994～2003年北京协和医院诊治的136例DM和PM患者的临床资料，分析其中6例并发头颈部恶性肿瘤患者的临床特点。结果：136例患者中，并发恶性肿瘤17例，其中头颈部恶性肿瘤6例：鼻咽癌4例，非霍奇金淋巴瘤1例，下咽癌1例，占恶性肿瘤的35．29％(6／17)。结论：鼻咽癌是DM和PM患者最易并发的头颈部恶性肿瘤；对于DM和PM患者，应该将鼻咽喉内镜检查列为常规，以期对潜在的头颈部恶性肿瘤做出早期诊断和治疗。

Dermatomyositis/polymyositis associated with head and neck malignancy

OBJECTIVE: To observe the relation between dermatomyositis/polymyositis and head-neck malignancy. METHOD: All 136 cases of dermatomyositis/polymyositis admitted to PUMCH during 10 years (1994-2003) were studied. The clinical features of 6 patients with an associated head-neck malignancy were analyzed. RESULT: There were 17 cases of malignancy in 136 patients with dermatomyositis/polymyositis, of which, 6 cases (6/17, 35.29%) were found to have head-neck malignancy: 4 cases of nasopharyngeal carcinoma, 1 case of non-Hodgkin lymphoma and 1 case of hypopharynx carcinoma. CONCLUSION: Nasopharyngeal carcinoma represents the first neoplasm among head-neck malignancy associated with dermatomyositis/polymyositis. Nasal endoscopic and/or fibrolaryngoscopic search for potential head-neck malignancy should be performed in every patient with dermatomyositis/polymyositis.