| 用高效抗逆转录病毒治疗HIV/HCV重叠感染33例 |
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| 引用本文： | 孙洪清,董婕,徐伟民.用高效抗逆转录病毒治疗HIV/HCV重叠感染33例[J].临床内科杂志,2003,20(8):402-404. |
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| 作者姓名： | 孙洪清 董婕 徐伟民 |
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| 作者单位： | 200083,上海传染病医院感染科 |
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| 摘 要： | 目的研究HIV/HCV重叠感染者用高效抗逆转录病毒治疗(HAART)的疗效和药物的副作用以及HIV和HCV的相互影响.方法治疗前后定期采集33例HIV/HCV重叠感染者的外周血,分离血桨和单个核细胞,检测病毒载量、T淋巴细胞亚群以及HCVRNA和肝脏纤维化指标.结果治疗后患者血浆中HIVRNA含量全部<50copies/ml,CD4不同程度增多.结论施多宁、拉米夫定和赛瑞特联合治疗HIV/HCV重叠感染者可有效抑制HIV-1的复制,并部分改善机体免疫功能.
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| 关 键 词： | 人免疫缺陷病毒感染 丙型肝炎病毒感染 高效抗逆转录病毒治疗 施多宁 拉米夫定 赛瑞特 |
| 文章编号： | 1001-9057(2003)08-0402-03 |
| 修稿时间： | 2003年6月10日 |
Highly active anti-retroviral Therapy on 33 cases of HIV/HCV superinfection |
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| SUN Hongqing,DONG Jie,XU Weiming.Highly active anti-retroviral Therapy on 33 cases of HIV/HCV superinfection[J].Journal of Clinical Internal Medicine,2003,20(8):402-404. |
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| Authors: | SUN Hongqing DONG Jie XU Weiming |
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| Institution: | SUN Hongqing,DONG Jie,XU Weiming Department of Infectious Diseases,Municipal Infectious Diseases Hospital Shanghai,Shanghai 200083,China |
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| Abstract: | Objective To investigate highly active anti retroviral therapy of HIV/HCV superinfection.Methods Thirty three patients with chronic HIV/HCV infection were recruited.Blood samples were collected before the treatment and different times after the initiation of HAART treatment.Result The drug regimen was effective in reducing HIV 1 plasma viral load and increasing total CD 4 T cell counts.Conclusions The combination of efavirenz and lamivudine and stavudine is generally well tolerated and effective in reducing HIV RNA.It also improves immune functions. |
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| Keywords: | HIV HCV HAART |
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