甘利欣保护重症急性胰腺炎肝损害的临床研究

目的: 观察甘利欣对重症急性胰腺炎(SAP)肝损害的保护作用。方法: 将48例SAP肝损害患者按照平行对照设计原理随机分为A组和B组,各24例,同时以健康志愿者24名作为正常对照组。A组采用常规治疗,B组采用常规治疗+甘利欣注射液治疗,以ELISA法测定血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6),以全自动生化分析仪测定血清丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、谷氨酰基转移酶(GGT)、总胆红素(TB)、直接胆红素(DB)。结果: B组入院第15天血清TNF-α、IL-6、ALT、AST、GGT、TB及DB浓度与入院时比较,降低程度均高于A组(P < 0.01)。结论: 甘利欣可能通过抑制SAP时的炎症反应,从而对SAP肝损害起保护作用。

An clinical study on protective effects of diammonium glycyrrihizine on liver injury caused by severe acute pancreatitis

Objective：To observe the protective effects of diammonium glycyrrihizine on liver injury caused by severe acute pancreatitis（SAP）.Methods：Forty-eight SAP patients with liver injury were randomly divided into group A（n=24） and B（n=24）.Patients in group A were treated with routine method,and patients in group B were treated with routine method plus diammonium glycyrrihizine injection.Twenty four normal individuals were used as control.The levels of serum tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6） were measured by ELISA.At the same time,the levels of serum alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,glutamyl transferase（GGT）,total bilirubin（TB） and direct bilirubin（DB） were measured by automatic biochemistry analyzer.Results：The levels of serum TNF-α,IL-6,ALT,AST,GGT,TB and DB decreased in both group A and B on the 15 d after admission,but the extent of reduction in group B was significantly higher than that in group A（P0.01）.Conclusions：Diammonium glycyrrihizine can inhibit inflammatory response in SAP,and play a protective role in liver injury caused by SAP.