苏红洗剂治疗骨性关节炎关节镜术后关节肿痛

目的:探讨中药苏红洗剂对膝关节骨性关节炎关节镜清理术后关节肿痛的影响及其作用机制。方法:收集2010年—2014年膝关节骨性关节炎患者90例,均行膝关节镜清理术手术治疗,术后随机分为A,B,C组,各30例。A组关节镜清理术伤口拆线后不使用药物;B组关节镜清理术伤口拆线后膝关节周围外用正红花油15 m L,早晚各1次,共用2周;C组关节镜清理术伤口拆线后膝关节外用苏红洗剂水煎外洗,每次15 min,早晚各1次,共用2周。进行一般疗效观察,记录治疗过程中的不良反应,治疗前后进行膝关节美国纽约特种外科医院(HSS)评分,抽取关节液进行一氧化氮(NO),超氧化物歧化酶(SOD),丙二醛(MDA)测定。结果:关节镜术后应用正红花油和苏红洗剂外用治疗,未见明显皮疹、过敏等不良反应,术后膝关节肿胀、疼痛均有缓解。治疗前后进行肝肾功检查无异常。采用苏红洗剂外洗能明显减轻膝关节肿痛症状,HSS评分优于对照组。苏红洗剂外洗能提高关节液SOD含量,降低关节液NO,MDA含量。结论:苏红洗剂通过提高关节液SOD含量,降低NO,MDA含量,以减轻骨关节炎关节镜术后关节的肿痛症状,改善膝关节的功能。

Suhong Lotion in Treating Articular Swelling and Pain After Osteoarthritis Arthroscopic Debridement

Objective: To observe the effect of Suhong lotion in treating articular swelling and pain after osteoarthritis arthroscopic debridement. Method: Totally 90 osteoarthritis patients after arthroscopic debridement during 2010 to 2014 were randomly divided into groups A, B, C. Group A was given with no medicine. Group B was treated with safflower oil for 2 weeks. Group C was externally treated with Suhong lotion for 2 weeks. Special surgery knee (HSS) score, nitrous oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA) were measured among all patients. Result: Articular swelling and pain was lessened, SOD content in synovia was increased, and NO, MDA content in synovia were decreased after washout with Suhong lotion. Conclusion: Washout with Suhong lotion after osteoarthritis arthroscopic debridement lessens articular swelling and pain and improves articular action by increasing SOD content in synovia, and decreasing NO, MDA content in synovia.