滇龙胆化学成分和药理作用研究进展

滇龙胆Gentiana rigescens为传统中草药,主产于中国云南、四川等地,具有悠久的药用历史,作为民间重要药物使用并记载。滇龙胆为龙胆科Gentianaceae多年生草本植物,主要化学成分为环烯醚萜苷类、三萜类、木脂素类、黄酮类、生物碱类、苯甲酸酯类和其他类化学成分,其主要药理作用包括保肝、利胆、镇痛、抗炎、抗氧化、促神经活化等。该文对滇龙胆中化学成分及其药理活性进行归纳总结,为滇龙胆的进一步开发和利用提供参考。

Research Advances in Chemical Constituents and Pharmacological Activity from Gentiana rigescens

Objective: Gentianarigescens,mainly distributed in Yunnan and Sichuan province of China, is widely known as traditional Chinese herbs in folk with long medicinal history. G. rigescens (Gentianaceae), is a kind of perennial herb, whose chemical constituents mainly include iridoids, triterpenes, lignans, flavanoids, alkaloids, gentisides and others. Their main pharmacological effects include liver protection, choleretic effect, analgesia, anti-inflammatory, anti-oxidant, promoting neural activation and so on.This paper would summarize the chemical constituents and pharmacological activity of G. rigescens, and provide reference for further development and utilization of G. rigescens.