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植物胶软胶囊新囊材的研究进展
引用本文:杨小侠,林华庆,罗锦杰.植物胶软胶囊新囊材的研究进展[J].中国实验方剂学杂志,2016,22(13):229-234.
作者姓名:杨小侠  林华庆  罗锦杰
作者单位:广东药科大学 药物研究所 广东省药物新剂型重点实验室, 广州 510006,广东药科大学 药物研究所 广东省药物新剂型重点实验室, 广州 510006,广东药科大学 药物研究所 广东省药物新剂型重点实验室, 广州 510006
基金项目:广东省省部产学研合作专项(201320)
摘    要:以植物胶替代明胶作为囊壳制备而成的软胶囊称之为植物胶软胶囊。随着明胶软胶囊的深入应用,其缺点越发突出,因而寻找软胶囊新囊材成为植物胶软胶囊市场发展的必然需求。目前植物胶软胶囊囊材的研究取得了一定的进展,已有多个专利申请成功,但鲜有成熟的产品上市。通过查阅近些年有关植物胶软胶囊的文献报道,本文对研究较为成熟的卡拉胶、淀粉、甘露聚糖胶、黄原胶和海藻酸钠5种植物胶软胶囊囊材进行了分类综述,阐述其凝胶机制及优缺点等。利用各种植物胶的优良性能进行复配,以弥补其单独使用时的缺陷,从而扩大植物胶的使用范围并提高其使用性能。对植物胶软胶囊的应用前景进行讨论与展望,提出其进一步研究方向,为新型植物胶软胶囊的开发应用提供思路与参考。

关 键 词:植物胶软胶囊  囊材  卡拉胶  淀粉  甘露聚糖胶  黄原胶  海藻酸钠
收稿时间:8/3/2015 12:00:00 AM

Advances in Researches of New Capsule Materials for Vegetable Gum Soft Capsules
YANG Xiao-xi,LIN Hua-qing and LUO Jin-jie.Advances in Researches of New Capsule Materials for Vegetable Gum Soft Capsules[J].China Journal of Experimental Traditional Medical Formulae,2016,22(13):229-234.
Authors:YANG Xiao-xi  LIN Hua-qing and LUO Jin-jie
Institution:Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Institute of Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China,Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Institute of Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China and Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Institute of Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China
Abstract:Soft capsules,which are made by vegetable gum replacing the gelatin as the capsule shell,are called vegetable gum soft capsules.With the deep application of gelatin soft capsule,its disadvantages become more prominent,so it is necessary to find a new capsule material for the development of soft capsule.Currently,vegetable gum soft capsules has made some progress with many patent applications,but few mature products come into the market.Based on consulting a large number of related literatures of vegetable gum soft capsules in recent years,this paper classified five kinds of soft capsule materials which has mature research,including the research status of carrageenan,starch,mannan gum,xanthan gum and sodium alginate,and their gel mechanism and advantages are discussed.Therefore,this article will discuss with the prospect of its application prospects and proposing further research,provide a reference for the development and application of new vegetable gum soft capsules.A variety of excellent performance of vegetable gum soft capsules were mixed to make up for the defects when used alone,thereby expanding the scope of use of vegetable gum soft capsules and improving its performance.
Keywords:vegetable gum soft capsules  capsule materials  carrageenan  starch  mannan gum  xanthan gum  sodium alginate
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