Perihilar cholangiocarcinoma arising in hepatitis C virus-related liver cirrhosis with hepatocellular carcinoma |
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Authors: | Takahiko Fujii Yoh Zen Yasuni Nakanuma |
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Institution: | (1) Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa 920-8640, Japan |
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Abstract: | Liver cirrhosis is reportedly one of the conditions preceding peripheral-type intrahepatic cholangiocarcinoma but not hilar/perihilar
cholangiocarcinoma. Herein, we report a case of perihilar cholangiocarcinoma arising in a hepatitis C virus-related cirrhotic
liver. The patient was a 69-year-old man. He was diagnosed with hepatitis C virus-related chronic hepatitis at the age of
56 years, and 9 years later, multiple hepatocellular carcinomas were detected by imaging modalities. Despite treatments, including
chemotherapy, he died of hepatic failure at the age of 69 years. At autopsy, in addition to multiple nodules of hepatocellular
carcinoma, we found a white mucinous and fibrous tumor spreading from the hepatic hilum to the periphery along the left lateral
segmental bile ducts in the advanced cirrhotic liver. This tumor was histologically a cholangiocarcinoma that involved mainly
the peribiliary glands and showed variable cystic dilation, suggesting that it might have been derived from these peribiliary
glands. Immunohistochemically, the cholangiocarcinoma cells were positive for cytokeratin 7 and mucin core protein 1, and
negative for cytokeratin 20 and mucin core protein 2. Hilar/perihilar cholangiocarcinoma arising in hepatitis C virus-related
liver cirrhosis has rarely been reported. This case warrants further studies to clarify the possible involvement of hepatitis
C virus in tumorigenesis of hilar/perihilar cholangiocarcinoma. |
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Keywords: | hepatitis C virus peribiliary glands cholangiocarcinoma liver cirrhosis peribiliary cysts |
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