血管细胞黏附分子在妊高征患者子宫胎盘床表达的意义

目的　探讨正常妊娠妇女和妊高征患者子宫胎盘床螺旋动脉滋养细胞血管细胞黏附分子 - 1(VCAM -1)表达水平的变化 ,以了解其与妊高征发病机理的关系。方法　采用免疫组织化学染色法检测 6 0例妊高征患者、 30例正常妊娠妇女子宫胎盘床螺旋动脉滋养细胞VCAM - 1的表达。结果　正常妊娠组孕妇子宫胎盘床螺旋动脉滋养细胞VCAM - 1的阳性表达率为 10 0 0 % ,妊高征组有 2 6例阳性表达 ,阳性表达率为 4 3 3% ,二者间差别有显著性意义 (P<0 0 5 ) ;中、重度妊高征组阳性表达率分别为 35 0 %和 10 0 % ,与正常妊娠组比较 ,差别均有显著性意义 (P <0 0 1) ;轻度妊高征组阳性表达率为 85 0 % ,与正常妊娠组比较 ,差别无显著性意义 (P >0 0 5 )。结论　妊高征患者子宫胎盘床螺旋动脉滋养细胞VCAM - 1表达减少可能与胎盘着床浅有关 ,而子宫胎盘着床表浅与妊高征的发病机制有关。

Significance of the Expression of VCAM-1 in Utero-Placental Bed with PIH

Objective To study the expression of VCAM-1 spiral arteries of utero-placental bed in PIH and normal pregnant woman,and to know the relationship with the genesis of PIH.Methods The expression of VCAM-1 spiral arteries of utero-placental bed in 60 women with PIH and 30 normal pregnant women were evaluated by immunohistochemistry.Results The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group (100%) were significantly higher than that in PIH group (P<0.05).The expression VCAM-1 in moderate PIH (35%) and sever PIH (10%) were lower than that in normal group.There was no difference between the mild PIH and normal group (P>0.05).Conclusion The reduced expression of VCAM-1 in utero-placental bed may relate with superficial implantation.VCAM-1 is relative to the genesis of PIH.