| 蛛网膜下腔出血患者内皮素测定的临床意义 |
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| 引用本文： | 郭沂涟,李义召,刘爱芬,孙琳,迟兆富.蛛网膜下腔出血患者内皮素测定的临床意义[J].山东大学学报(医学版),2001,39(2):134-135. |
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| 作者姓名： | 郭沂涟 李义召 刘爱芬 孙琳 迟兆富 |
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| 作者单位： | 1. 山东大学第二医院神经内科
2. 山东大学齐鲁医院神经内科 |
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| 摘 要： | 探讨内皮素(ET)在蛛网膜下腔出血(SAH)发生发展中的作用。方法采用放射免疫
分析法检测36例SAH患者血浆ET浓度。结果①SAH组ET含量为(127.45±11.30)ng/L，明显高于对照组的(66.75±7.23)ng/L(P<0.001)；②血浆ET浓度动态变化规律发病24h内开始升高，半月内持续偏高(4～7d达高峰)，之后下降，发病1月后恢复正常，与SAH后脑血管痉挛(CVS)的时程相一致；③有症状性血管痉挛者ET含量为(166.42±12.12)ng/L明显高于无症状性血管痉挛者的(96.86±10.08)ng/L(P<0.001)；④血浆ET浓度与病情轻重及是否合并其他脏器损害有关重型为(161.63±12.80)ng/L，明显高于轻型的(99.96±6.08)ng/L(P<0.001)；合并其他脏器损害者为(155.33±11.15)ng/L明显高于单纯SAH的(103.05±12.53)ng/L(P<0.001)。结论内皮素在SAH的发生发展尤其是在SAH后的CVS中起着重要的作用，测定其浓度有助于判断病情预后。
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| 关 键 词： | 内皮缩血管肽类 蛛网膜下腔出血 放射免疫测定 |
| 文章编号： | 1000-0496(2001)02-0134-02 |
| 修稿时间： | 2000年1月4日 |
CLINICAL SIGNIFICANCE OF
ENDOTHELIN DETECTION OF PATIENTS WITH SUBARACHNOID HEMORRHAGE |
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| GUO Yi lian,LI Yi zhao,LIU Ai fen,et al.CLINICAL SIGNIFICANCE OF
ENDOTHELIN DETECTION OF PATIENTS WITH SUBARACHNOID HEMORRHAGE[J].Journal of Shandong University:Health Sciences,2001,39(2):134-135. |
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| Authors: | GUO Yi lian LI Yi zhao LIU Ai fen |
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| Abstract: | To investigate the role of enothelin (ET) in patients with subarachnoid hemorrhage(SAH). Methods:The changes of ET in plasma of 36 patients with SAH was observed by radioimmunoassay. Results: ①The levels of ET in SAH group(127.45±11.30)ng/L] were higher than those of normal group (66.75±7.23)ng/L] significantly(P<0.001). ②The levels of ET in SAH group elevated in 24 hours, and lasted for 15d(reaching the peak during 4～7d),then began to descend and recovered to normal level 30d later after the onset of SAH.③The levels of ET in SAH with cerebral vasospasm(CVS)〔(166.42±12.12)ng/L〕were significantly higher than those of without CVS 〔(96.86±10.08)ng/L〕(P<0.001). Conclusion: ET
plays a key role in the pathogenesis of SAH and can be used as an important prognosis indicator |
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| Keywords: | Endothelins Subarachnoid hemorrhage Radioimmunoassay |
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