Cutaneous lymphoepithelioid lymphoma (Lennert's lymphoma). Combined immunohistological, ultrastructural, and DNA-flow-cytometric analysis |
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| Authors: | F Kiesewetter E Haneke K Lennert O P Hornstein M Fartasch |
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| Affiliation: | Department of Dermatology, University of Erlangen-Nürnberg, FRG. |
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| Abstract: | Lymphoepithelioid lymphoma (LEL) is a peculiar type of low grade malignant T cell lymphoma usually arising in lymph nodes, characterized immunohistologically by predominant T-helper/inducer lymphocytes intermingled with clusters of epithelioid cells. An uncommon case of LEL with cutaneous involvement is reported with additional reference to ultrastructure and DNA-flow-cytometric analysis (DNA-FCM) of the lymphoma. Light microscopy showed subepidermal bandlike infiltrates of lymphocytes and clusters of epithelioid cells extending into the subcutaneous tissue. By immunohistochemistry the presence of a high percentage of T-helper/inducer lymphocytes was confirmed. DNA-FCM demonstrated an aneuploid cell population indicating malignant cells. Our results are in accordance with earlier ones established in lymph nodes. |
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