Acute kidney injury secondary to renal large B-cell lymphoma: role of early renal biopsy |
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Authors: | Suhail Al-Salam Ahmad Shaaban Maha Alketbi Naveed U Haq Samra Abouchacra |
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Institution: | (1) Pathology Department, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE;(2) Nephrology Department, Tawam Hospital, Al Ain, UAE |
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Abstract: | Renal involvement in large B-cell lymphoma represents an exceptional manifestation of non-Hodgkin lymphomas. Acute kidney
injury (AKI) by lymphomatous infiltration is extremely rare and so far only 19 cases have been reported in the literature.
We report a 67-year-old woman who presented with AKI and was found to have large B-cell lymphoma infiltrating her kidneys.
The patient was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab, and a dramatic
improvement of renal function was noticed after two weeks of treatment. Her renal function completely recovered after four weeks
of treatment. In conclusion, lymphomatous infiltration of kidneys can directly lead to AKI. Rapid diagnosis and treatment
is essential to preserve the renal function. Renal biopsy is the gold standard for the early diagnosis of non-Hodgkin lymphoma
as a cause of AKI. |
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