Granular acute lymphoblastic leukemia with hypereosinophilic syndrome |
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| Authors: | P. Jain R. Kumar S. Gujral A. Kumar A. Singh Y. Jain S. Dubey M. Anand L. S. Arya |
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| Affiliation: | (1) Unit of Laboratory Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India, IN;(2) Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India, IN;(3) All India Institute of Medical Sciences (AIIMS), E-99, AIIMS Main Campus, Ansari Nagar (East), New Delhi 110029, India Tel.: +91-11-6594988, +91-11-6863881 Fax: +91-11-6862663 e-mail: paresh@medinst.ernet.in e-mail: pareshjain@hotmail.com, IN |
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| Abstract: | 9 /l), features of hypereosinophilic syndrome, and acute lymphoblastic leukemia (ALL-L2), the latter characterized by the presence of granular blasts. Blasts were negative for myeloperoxidase, non-specific esterase, acid phosphatase, periodic-acid Schiff stain, and toluidine blue. They exhibited an early pre-B immunophenotype (TdT, CD19, CD10, CD20 and CD22 positive) and stained negative for T (CD7, CD2, CD5 and CD3) and myeloid markers (MPO, CD33 and CD13). Chromosomal analysis revealed a normal karyotype. To the best of our knowledge, this case represents the first report of the coexistence of granular ALL and hypereosinophilic syndrome. Received: 11 May 1999 / Accepted: 20 October 1999 |
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| Keywords: | Acute lymphoblastic leukemia Granular lymphoblasts Eosinophilia Hypereosinophilic syndrome |
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