7例原发性乳腺鳞形细胞癌的角蛋白免疫组织化学与雌激素受体检测

乳腺鳞癌是一种少见的乳癌类塑,其发病率为0.05～0.2％。本教研室从1959～1986年共收集得原发乳腺鳞癌7例,占同期女性乳腺癌的0.24％、发病年龄为35～73岁不等。其中5例分化好有明显角化珠,2例分化较差。7例角蛋白组化染色均里阳性结果,其中3例同时作电镜超微结构观察并作雌激素受体检测,结果为阴性。2例癌旁组织显示乳腺导管扩张伴鳞化,其中1例在癌组织中见到内衬鳞形上皮的小囊腔,支持了乳腺鳞癌可能来源于导管上皮的论点。

KERATIN IMMUNOHISTOCHEMICAL STAIN AND ESTROGENRECEPTOR ASSAY OF 7 CASES OF PRIMARY SQUAMOUSCARCINOMA OF THE BREAST

Primary squamous carcinoma of the breast is a rare type of breast cancer, its Incidence is 0.05-0.2%. During 1959-1986 only 7 cases were collected which accounted for 0.24% of breast cancer at the same period, the patient's age varied from 35-73 averaging age of 54.Among 7 oases, 5 cases were well differentiated and 2 cases were poor differentiated, in immunohistoohemioal assay, all of 7 oases showed positive of keratin stain, 3 frozen section cases with estrogen receptor assay showed negative, under electron microscope, the desmosones and tonofilaments of cancer cells could be found. .There was a small cyst lining squamous cells with dysplasia in the tumor tissue of the breast, the dilated ducts with squamous metaplasia could be seen in the adjecent tissue of the breast cancer. These evidences are helpful to the hypothesis of the ductal origin of the primary squamous carcinoma of the breast histologioally.