| KAI1基因表达和淋巴管生成对非小细胞肺癌淋巴结转移的影响 |
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| 引用本文： | 黎传奎,王祖义,王萍,刘学刚,唐震,汪国文. KAI1基因表达和淋巴管生成对非小细胞肺癌淋巴结转移的影响[J]. 蚌埠医学院学报, 2010, 35(2): 124-126. DOI: 10.3969/j.issn.1000-2200.2010.02.006 |
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| 作者姓名： | 黎传奎 王祖义 王萍 刘学刚 唐震 汪国文 |
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| 作者单位： | 1. 安徽省蚌埠市第一人民医院胸心外科, 233000;2. 蚌埠医学院第一附属医院胸心外科, 安徽蚌埠 233004;3. 蚌埠医学院病理学教研室, 安徽蚌埠 233030 |
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| 基金项目： | 安徽省教育厅自然科学研究资助项目(KJ2008B53ZC) |
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| 摘 要： | 目的:探讨非小细胞肺癌(non-small cell lung cancer,NSCLC) KAI1基因表达下调和淋巴管生成对淋巴结转移是否具有协同作用。方法:应用兔抗人多克隆抗体KAI1和兔抗人抗Podoplanin单克隆抗体(EliVision法)对68例NSCLC组织石蜡切片进行染色,Logistic回归分析判断转移抑制基因KAI1的表达和淋巴管生成与淋巴结转移的关系。结果:NSCLC淋巴结阳性组和淋巴结阴性组KAI1表达阳性率分别为30.3%和88.6%,两者差异有统计学意义(P<0.01)。肿瘤间质中淋巴结阳性患者淋巴管密度(lymphatic vessel density,LVD)为15.73±0.74,明显高于淋巴结阴性患者8.31±0.32(P<0.01)。Logistic回归分析显示,仅LVD对淋巴结转移有影响(P<0.05),其相对危险度(OR)为2.065,95%可信区间(1.202,3.547);而KAI1表达下调无统计学意义(P=0.375),95%可信区间为(0.003,8.714)。NSCLC患者转移抑制基因KAI1的表达下调和肿瘤间质中淋巴管生成对淋巴结转移无明显协同作用(P>0.05)。结论:肿瘤转移抑制基因KAI1表达下调与淋巴管生成对NSCLC淋巴结转移有促进作用,但未见明显协同作用。
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| 关 键 词： | 癌 非小细胞肺 肿瘤转移抑制基因 KAI1 淋巴管生成 淋巴管密度 |
| 收稿时间： | 2009-04-24 |
Association of metastasis suppressor gene KAI1 expression and lymphangiogenesis with non-small cell lung cancer and its clinical significance |
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| LI Chuan-kui,WANG Zu-yi,WANG Ping,LIU Xue-gang,TANG Zhen,WANG Guo-wen. Association of metastasis suppressor gene KAI1 expression and lymphangiogenesis with non-small cell lung cancer and its clinical significance[J]. Journal of Bengbu Medical College, 2010, 35(2): 124-126. DOI: 10.3969/j.issn.1000-2200.2010.02.006 |
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| Authors: | LI Chuan-kui WANG Zu-yi WANG Ping LIU Xue-gang TANG Zhen WANG Guo-wen |
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| Affiliation: | 1. Department of Cardiovascular and Thoracic Surgery, Bengbu First People's Hospital, Bengbu Anhui 233000;2. Department of Cardiovascular and Thoracic Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004;3. Department of Pathology, Bengbu Medical College, Bengbu Anhui 233030, China |
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| Abstract: | Objective:To study the synergy between down-regulation or lack of KAI1(one of metastasis suppressor genes) and metastasis of lymph node in non-small cell lung carcinoma(NSCLC).Methods:The expression of KAI1 and Podoplanin which was used to show lymphatic vessel density(LVD) were detected in 68 paraffin sections of NSCLC with immunohistochemistry(EliVision methods),and logistic regression analysis was used to show the relationship between the expression and metastasis of lymph nodes.Results:The positive rate... |
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| Keywords: | carcinoma non-small cell lung cancer tumor metastasis suppressor gene KAI1 lymphangiogenesis lymphatic vessel density |
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