Effect of Tumor Deposits on Overall Survival in Colorectal Cancer Patients
with Regional Lymph Node Metastases |
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Authors: | Eiichi Yabata Masaru Udagawa Hiroyuki Okamoto |
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Institution: | Department of Surgery, JA Toride Medical Center, Japan |
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Abstract: | Objectives: The staging system of the International Union Against Cancer
considers tumor deposits to be N1c in patients with no regional lymph node metastasis, but
the significance of tumor deposits in patients with regional lymph node metastases is
unclear. We investigated the effect of tumor deposits on overall survival in colorectal
cancer patients with regional lymph node metastases.Patients and Methods: From 2000 to 2008, 551 patients underwent resections
for colorectal cancer at our medical center. We excluded 87 patients who had distant
metastases or had received neoadjuvant chemotherapy or radiotherapy from our study and
statistically analyzed the remaining 464 patients.Results: Stepwise multivariate Cox proportional hazards analysis in patients
with regional lymph node metastases showed only tumor deposits to be significant for
overall survival (hazard ratio: 2.813; P = 0.0002). Recurrence was seen
in 49.2% of patients with tumor deposits (30/61) compared with 14.4% of patients without
them (58/403; P < 0.0001). Tumor deposits did not show the same effect
on overall survival as lymph node metastases.Conclusions: Tumor deposits were significantly associated with poorer
overall survival in colorectal cancer patients with regional lymph node metastases. The
effect of tumor deposits on overall survival was between that of lymph node metastasis and
distant metastasis. |
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Keywords: | tumor deposits overall survival colorectal cancer lymph node metastasis |
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