Multiple malignancies in a female patient with common variable immunodeficiency syndrome |
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| Authors: | Milena Todorovic Bela Balint Bosko Andjelic Biljana Mihaljevic |
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| Institution: | 1.Clinic for Hematology, Clinical Center of Serbia, Belgrade, Serbia;2.Faculty of Medicine, University of Belgrade, Belgrade, Serbia;3.Institute for Transfusiology and Hemobiology of MMA, Belgrade, Serbia;4.Institute for Medical Research, University of Belgrade, Belgrade, Serbia |
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| Abstract: | We herein present the case of a 55-year-old woman with a previous history of malignancies – uterine adenocarcinoma, basal cell carcinoma (which occurred twice consecutively), recurrent respiratory infections due to common variable immunodeficiency (CVID), and systemic granulomatous disease diagnosed at a later age. The patient suffered from diffuse large B cell lymphoma (DLBCL), which was successfully treated with R-CHOP chemotherapy, and continued with immunoglobulin supplementation. The patient was free of lymphoma and infectious complications for over 20 months despite her persistent immunodeficiency, but eventually developed colorectal adenocarcinoma. To the best of our knowledge, this is the first reported case of CVID associated with multiple solid tumours and DLBCL. |
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| Keywords: | common variable immunodeficiency diffuse large B cell lymphoma multiple carcinomas |
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