Reduction of postprandial glycemic excursions in patients with type 1 diabetes: a novel human insulin formulation versus a rapid-acting insulin analog and regular human insulin |
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Authors: | Heinemann Lutz Hompesch Marcus Flacke Frank Simms Patrick Pohl Rody Albus Kerstin Pfützner Andreas Steiner Solomon |
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Institution: | 1Profil Institut für Stoffwechselforschung, Neuss, Germany;2Profil Institute for Clinical Research, Inc., San Diego, California;3Biodel Inc., Danbury, Connecticut;4IKFE, Institute for Clinical Research and Development, Mainz, Germany |
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Abstract: | Background:Evaluation of postprandial glycemic excursions in patients with type 1 diabetes with three prandial insulins: VIAject? (Linjeta?), an ultra-fast insulin (UFI); insulin lispro (LIS); and regular human insulin (RHI).Methods:After stabilization of preprandial glycemia, 18 patients received a subcutaneous injection with an individualized insulin dose prior to a meal.Results:Injection of UFI resulted in a more rapid insulin absorption than with either LIS or RHI (time to half-maximal insulin levels: 13.1 ± 5.2 vs 25.4 ± 7.6 and 38.4 ± 19.5 min; p = .001 vs LIS and p < .001 vs RHI, LIS vs. RHI p < .001). Maximal postprandial glycemia was lower with UFI (0–180 min; 157 ± 30 mg/dl; p = .002 vs RHI) and LIS (170 ± 42 mg/dl; p = .668 vs RHI) than after RHI (191 ± 46 mg/dl; RHI vs LIS p = .008). The difference between maximum and minimum glycemia was smaller with UFI (70 ± 17 mg/dl) than with either RHI (91 ± 33 mg/dl; p = .007 vs UFI) or LIS (89 ± 18 mg/dl; p = .011 vs UFI). Also, the area under the blood glucose profile was lower with UFI than with RHI (0–180 min; 21.8 ± 5.8 vs 28.4 ± 7.6 g·min/dl; p < .001).Conclusions:The rapid absorption of UFI results in a reduction of postprandial glycemic excursions. |
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Keywords: | insulin therapy meal-time insulin prandial insulin rapid-acting insulin analogs ultra-fast insulin ultra-rapid insulin |
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