Prothrombin times and activated partial thromboplastin times in toxicology: a comparison of different blood withdrawal sites for wistar rats |
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| Authors: | P J M Salemink J Korsten and P de Leeuw |
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| Institution: | (1) Department of Drug Safety, Organon Int. BV, Oss, The Netherlands;(2) Dept. of Drug Safety, Organon Int. BV, PO Box 20, 5340 BH, Oss, The Netherlands |
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| Abstract: | The prothrombin time (PT) and the activated partial thromboplastin time (APTT) for untreated male Wistar rats were determined on the Sysmex CA-5000 Instrument for blood taken from the orbital sinus, tail vein, vena cava and aorta. Boxplot and statistical analysis was performed. Only orbital sinus puncture yields unpredictable and unacceptable variation/prolongation of clotting times. |
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| Keywords: | APTT Blood withdrawal PT Rat Sysmex CA-5000 |
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