普萘洛尔与维拉帕米治疗药物性窦性心动过速的比较

目的：用双盲对照法比较普萘洛尔与维拉帕米治疗抗精神病药所致窦性心动过速（简称窦速）的疗效。方法：因服抗精神病药物后引起窦速１００例，分为甲、乙２组。甲组５０例（男性３１例，女性１９例；年龄３２±ｓ１３ａ）采用普萘洛尔１０ｍｇ，ｐｏ，ｔｉｄ×２ｗｋ．乙组５０例（男性３１例，女性１９例；年龄３３±１２ａ）采用维拉帕米２０ｍｇ，ｐｏ，ｔｉｄ×２ｗｋ。结果：甲组痊愈４３例，有效７例；乙组痊愈１９例，有效２１例，无效１０例，经Ｒｉｄｉｔ分析法统计，Ｐ＜０．Ｏ５；２组均无明显不良反应。结论：治疗抗精神病药物性引起的窦速普萘洛尔优于维拉帕米。

Propranolol vs verapamil in treating drug-induced sinus tachycardia

AIM:To compare propranolol and verapamil in treating sinus tachycardia induced by antipsychotic drugs. METHODS: By double-blind controlled trial 100 patients were equally divided into 2 groups: A) M 31,F19, age 32± s 13,ceived propranolol 10 mg, po,tid ×2wk; B) M 31, F 19,age 33± 12 a, received verapamil 20 mg,po,tid × 2 wk. RESULTS: In group A,43 patients were cured,7 patients were effective,In group B,19 patients were cured,21 patients were effective,and 10 patients had no response. Adverse reactions were mild in the 2 groups. CONCLUSION: Propranolol is better than verapamil in treating sinus tachycardia induced by antipsychotic drugs.